Investigating the effects of ancestral stress, environmental enrichment and the concept of allostatic load

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dc.contributor.authorMcCreary, J. Keiko
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2016-04-13T17:39:30Z
dc.date.available2016-04-13T17:39:30Z
dc.date.issued2016
dc.degree.levelPh.Den_US
dc.description.abstractThe stress that our ancestors experienced resonates with us in their stories, and memoires, but does it affect our health? In this thesis, the impact of ancestral stress on offspring was investigated. We hypothesized that ancestral stress has a significant impact on the development of the stress response, neuromorphology, and behaviour. Moreover, as stress is multi-systematic in its effects, this study examined the use of a new stratification tool termed the cumulative animal allostatic load index (CAALM). In addition, we tested the influence of postnatal enriched environment (EE) on ancestral stress-induced deficits. Lastly, we investigated a “two-hit hypothesis” of maternal stress and inflammation on offspring development. Overall, results indicate that ancestral stress is transferred across generations and increases allostatic load, and EE reverses detrimental effects. Moreover, inflammation exacerbates the effect of stress. Altogether, our results shed light on the influence of maternal and ancestral health on offspring development and the benefit of EE.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4467
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectallostatic loaden_US
dc.subjectancestral stressen_US
dc.subjectenriched environmenten_US
dc.subjectinflammationen_US
dc.subjectmaternal stressen_US
dc.subjectoffspring developmenten_US
dc.titleInvestigating the effects of ancestral stress, environmental enrichment and the concept of allostatic loaden_US
dc.typeThesisen_US
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