Neural changes in forelimb cortex and behavioural development

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dc.contributor.authorColes, Brenda Louise Kay
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWhishaw, Ian Q.
dc.date.accessioned2007-04-20T21:54:52Z
dc.date.available2007-04-20T21:54:52Z
dc.date.issued1996
dc.degree.levelMasters
dc.descriptionx, 132 leaves : ill. ; 28 cm.en
dc.description.abstractNeural changes in the forelimb cortex were studied at Postnatal (P) 10, 15, 20, 25, 30, and 100 days. Six biological markers of brain development, cortical thickness, Layer III pyramidal cell morphology, glial fibrillary acidic protein (GFAP), myelination, c-fos activity and Acetylcholinesterase (AChE) were correlated with the behavioural development of reaching, bimanual coordination, postural adjustment, and defensive feeding behaviours. The behaviours were filmed from P15 until P30 and then also in adulthood. For the behaviours there was a gradual development of the skilled patterns of paw and digit use seen in adults as well as in the patterns of movements in postural adjustment, carry behaviours and dodging and robbing type behaviours. The development of the adult patterns of movement were correlated to the morphological and biochemical changes in the cortex. The results suggest that the maturation of skilled movements depends upon anatomical and neurochemical maturation of the neocortex as well as upon learning.en
dc.identifier.urihttps://hdl.handle.net/10133/85
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1996en
dc.publisher.departmentDepartment of Psychology
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectPrefrontal cortexen
dc.subjectDevelopmental psychologyen
dc.subjectRodents -- Physiologyen
dc.subjectRats as laboratory animalsen
dc.subjectDissertations, Academicen
dc.titleNeural changes in forelimb cortex and behavioural developmenten
dc.typeThesisen
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