The hippocampus, retrograde amnesia, and memory deconsolidation

dc.contributor.authorEpp, Jonathon
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2007-05-12T20:34:51Z
dc.date.available2007-05-12T20:34:51Z
dc.date.issued2005
dc.degree.levelMasters
dc.descriptionx, 78 leaves : ill. ; 29 cm.en
dc.description.abstractThere are numerous clinical and experimental accounts of retrograde and anterograde amnesia resulting from damage to the hippocampus (HPC). Several theories on the HPC hold that only certain types of recent memories should be affected by HPC damage. These theories do not accurately predict the circumstances within which memories are vulnerable to HPC damage. Here I show the HPC plays a role in the formation and storage of a wider range of memories than is posited in contemporary theories. I will demonstrate that an important factor in elciting retrograde amnesia is the number of similar learning episodes. Exposure to multiple problems in the same task context leads to retorgrade amnesia that is not observed when only one problem is learned under otherwise identical parameters. When multiple discriminations are learned, the output of the HPC blocks recall from and future use of the extra-HPC memory system.en
dc.identifier.urihttps://hdl.handle.net/10133/219
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectMemory -- Physiological aspectsen
dc.subjectMemory -- Researchen
dc.subjectRats as laboratory animalsen
dc.subjectHippocampus (Brain) -- Physiologyen
dc.subjectAmnesia -- Researchen
dc.subjectMemory disordersen
dc.titleThe hippocampus, retrograde amnesia, and memory deconsolidationen
dc.typeThesisen
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