The fear conditioned response under head fixation

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dc.contributor.authorNaghizadeh, Milad
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2021-01-07T16:52:54Z
dc.date.available2021-01-07T16:52:54Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractIn classic measures of fear induced freezing behavior, animals stop all movement except breathing. Many large-scale recording techniques in modern neuroscience such as wide-field and two-photon fluorescent imaging require animals be in a head-fixed preparation. Here we demonstrate that it is possible to measure freezing behavior in head-fixed mice based on video measurements of motion, the pupillary response, and electromyography of neck muscles. Animals were either conditioned to form an association between a tone (conditioned stimulus; CS) and a footshock (unconditioned stimulus; US) or were presented both tones and footshocks explicitly unpaired. Animals who were conditioned to form an association showed less movement, and a stronger pupil response when presented with the CS. We outline key considerations which are likely important in establishing a strong fear response in a head-fixed preparation.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5819
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectBehavioral sciences [0602]en_US
dc.proquest.subjectBehavioral psychology [0384]en_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectDissertations, Academicen_US
dc.subjectFearen_US
dc.subjectFear in animalsen_US
dc.subjectEmotions in animalsen_US
dc.subjectPsychologyen_US
dc.titleThe fear conditioned response under head fixationen_US
dc.typeThesisen_US
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