Investigating hippocampal-neocortical interactions around sharp-wave ripples

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dc.contributor.authorKarimi Abadchi, Javad
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2022-03-09T20:41:44Z
dc.date.available2022-03-09T20:41:44Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractCoordinated activity in the hippocampal-neocortical network around hippocampal sharp-wave ripples (SWRs) plays an instrumental role in memory processing in the brain. SWRs occur in both sleep and awake states, though under two significantly different behavioural and chemical circumstances. Previous studies have reported different patterns of peri-SWR neocortical modulations between these states; however, their findings have been limited to one or a few discrete regions of the neocortex. To extend previous findings, we conducted wide-field optical imaging of the mouse neocortical voltage and glutamate activity combined with hippocampal electrophysiological recording. We found topographically- and temporally-organized patterns of neocortical glutamate and voltage activity around sleep and awake SWRs, though with pronounced differences. These findings highlight the state-dependency of the hippocampal-neocortical network’s computations and possibly functions. Moreover, they provide a spatiotemporal map of the neocortex around SWRs that could guide future studies on the role of hippocampal-neocortical interactions in memory consolidation.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6156
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectsharp-wave rippleen_US
dc.subjectmemoryen_US
dc.subjecthippocampusen_US
dc.subjectneocortexen_US
dc.subjectconsolidationen_US
dc.subjectMemory--Researchen_US
dc.subjectMemory--Physiological aspectsen_US
dc.subjectMemory consolidation--Researchen_US
dc.subjectHippocampus (Brain)--Researchen_US
dc.subjectNeocortex--Researchen_US
dc.subjectOscillationsen_US
dc.subjectNeural circuitryen_US
dc.subjectDissertations, Academicen_US
dc.titleInvestigating hippocampal-neocortical interactions around sharp-wave ripplesen_US
dc.typeThesisen_US
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