Species differences in selenium toxicity : linking cellular responses to population effects

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dc.contributor.authorMiller, Lana L.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorHontela, Alice
dc.date.accessioned2012-03-09T21:40:27Z
dc.date.available2012-03-09T21:40:27Z
dc.date.issued2011
dc.degree.disciplineBiological Sciences
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxiv, 171 leaves : ill., maps ; 29 cmen_US
dc.description.abstractModel organisms are often used in ecotoxicological studies and environmental risk assessments; however, species differences in responses to toxicants exist. A meta-analysis identified normal biomarker ranges for rainbow trout (RT) and brook trout (BT), and showed that RT had greater whole-body lipids and plasma T4 levels than BT. Exposure to selenium inhibited cortisol secretion of trout adrenocortical cells; however, RT were more sensitive than BT. To investigate species vulnerability at the individual level, RT and BT were stocked into reference and selenium-contaminated pit lakes. Fish accumulated more Se from selenium-contaminated than reference lakes, and selenium accumulation was similar between species. Chronic selenium exposure had a greater energetic cost for RT than BT, but this was mitigated by food availability. Chronic selenium exposure decreased plasma T3 and T4 levels, but did not alter other endocrine or oxidative stress biomarkers. This project highlights the need for both species- and site-specific risk assessments.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2622
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2011en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrook trout -- Effect of selenium on -- Researchen_US
dc.subjectRainbow trout -- Effect of selenium on -- Researchen_US
dc.subjectEnvironmental toxicology -- Researchen_US
dc.subjectBiochemical markersen_US
dc.subjectDissertations, Academicen_US
dc.titleSpecies differences in selenium toxicity : linking cellular responses to population effectsen_US
dc.typeThesisen_US
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