Cell therapy limits loss of vision in an animal model of retinal degenerative disease

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dc.contributor.authorMcGill, Trevor
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorPrusky, Glen
dc.date.accessioned2007-05-23T17:30:09Z
dc.date.available2007-05-23T17:30:09Z
dc.date.issued2004
dc.degree.levelMasters
dc.descriptionvii, 77 leaves ; 29 cm.en
dc.description.abstractThe Royal College of Surgeons (RCS) rat was used as a model of human retinal degenerative disease, and for studying the efficacy of cell transplanation treatments. In order to characterize the spatial vision of the RCS strain, the visual acutiy and contrast sensitivity of adult non-dystrophic RCS rats was measured. The acuity and contrast sensitivity of these rats was normal. The acuity of dystrophic RCS rats was alos characterized to determine how photoreceptor degeneration affects vision. These rats progressively lost visual acuity from one month of age until elevn months of age when they were judged to be blind. The degeneration of vision in these animals was more protacted than would be predicted from previous anatomical and electrophysiological measures. Subretinal transplantation of human-derived Retinal Pigment Epithelial (RPE) cells and human Schwann cells into the dystrophic RCS rat significantly delayed the loss of visual acuity. These studies show that cell transplantation may be a viable method of limiting loss of vision in humans with retinal degenerative blinding diseases.en
dc.identifier.urihttps://hdl.handle.net/10133/274
dc.language.isoen_USen
dc.publisherLethbridge, AB : University of Lethbridge, Faculty of Arts and Science, 2004en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectRetinal degeneration -- Researchen
dc.subjectCell transplantation -- Researchen
dc.subjectRetina -- Diseases -- Researchen
dc.subjectCellular therapy -- Researchen
dc.titleCell therapy limits loss of vision in an animal model of retinal degenerative diseaseen
dc.typeThesisen
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