Using rapid kinetics and molecular dynamics simulations to study biomolecular information processing and design

Simple item page
dc.contributor.authorDe Laurentiis, Evelina I.
dc.contributor.authorGirodat, Dylan J.
dc.contributor.authorMercier, Evan
dc.contributor.authorWieden, Hans-Joachim
dc.date.accessioned2019-06-26T18:24:01Z
dc.date.available2019-06-26T18:24:01Z
dc.date.issued2016
dc.descriptionOpen access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) appliesen_US
dc.description.abstractTranslation, the ribosome dependent synthesis of proteins, is the last step of gene expression. It is targeted by a large number of antibiotics that modulate, in one way or the other, the dynamic properties of the involved biomolecules. Protein synthesis is a highly conserved multi-step process facilitated by a large ribonucleoprotein complex (the ribosome) acting as a biomolecular assembler, converting genetic information provided as RNA transcripts (mRNA) into proteins. This process occurs with high speed and incredible accuracy within any living system (1). As such, accuracy is the key to maintaining the integrity of the genetic information to be reflected in the resulting proteins. The underlying design principles that enable the translation machinery to achieve these performance characteristics is of great interest for a large number of fields and applications, naming antibiotics design and the rational engineering of biomolecular machines just as two examples.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationDe Laurentiis, E. I., Girodat, D., Mercier, E., & Wieden, H.-J. (2016). Using rapid kinetics and molecular dynamics simulations to study biomolecular information processing and design. Biomath Communications, 3(1), 1604167. http://dx.doi.org/10.11145/bmc.2016.04.167en_US
dc.identifier.urihttps://hdl.handle.net/10133/5434
dc.language.isoen_USen_US
dc.publisherBiomath Forumen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttp://dx.doi.org/10.11145/bmc.2016.04.167
dc.subjectTranslationen_US
dc.subjectBioengineeringen_US
dc.subjectMolecular dynamics simulationsen_US
dc.subjectRapid kineticsen_US
dc.subjectGTPasesen_US
dc.subjectNucleotide exchangeen_US
dc.subjectElongation Factor Tuen_US
dc.subjectStoppedflowen_US
dc.subjectFluorescenceen_US
dc.subjectStructural dynamicsen_US
dc.subjectP-loop anchoren_US
dc.titleUsing rapid kinetics and molecular dynamics simulations to study biomolecular information processing and designen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Wieden-using-rapid-kinetics.pdf
Size:
669.59 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Wieden, Hans-Joachim