Elucidating the role of SINE non-coding RNAs in amyloid beta pathology

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dc.contributor.authorCheng, Yubo
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorZovoilis, Athanasios
dc.contributor.supervisorPatel, Trushar R.
dc.date.accessioned2021-11-23T21:45:39Z
dc.date.available2021-11-23T21:45:39Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractDespite recent advances in our understanding of gene expression networks in Alzheimer's disease (AD), the molecular mechanisms of its pathogenesis still remain unclear. Previous studies have shown that mechanisms involving non protein-coding RNAs transcribed by Short Interspersed Nuclear Element (SINE) are key in maintaining transcriptional homeostasis in cells. RNAs from SINE B2 repeats in mouse and SINE Alu repeats in human, control gene expressions through binding and inhibition of RNA Polymerase II. Here, an integrative RNA genomics and bioinformatics approach is applied to investigate the connection between SINE RNAs, amyloid beta neuro-toxicity and dementia both in mouse models of AD and brains of AD patients. Our data shows that processing of SINE RNAs is abnormally increased in response to amyloid beta toxicity, and is connected with deregulation of gene expression during amyloid beta pathology and AD.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6096
dc.language.isoen_USen_US
dc.proquest.subject0715en_US
dc.proquest.subject0369en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistryen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectnon-coding RNAen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectSINE RNAsen_US
dc.subjectamyloid beta neuro-toxicityen_US
dc.subjectgene expression deregulationen_US
dc.subjectNon-coding RNA -- Researchen_US
dc.subjectAlzheimer's disease -- Researchen_US
dc.subjectAmyloid beta-proteinen_US
dc.subjectTransposons -- Researchen_US
dc.subjectMobile genetic elementsen_US
dc.subjectGenetic transcription -- Regulationen_US
dc.subjectDissertations, Academicen_US
dc.titleElucidating the role of SINE non-coding RNAs in amyloid beta pathologyen_US
dc.typeThesisen_US
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