Maintenance and Behavioural Expression of Long-term Memories Acquired in the Absence of the Hippocampus

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dc.contributor.authorGidyk, Darryl C.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2019-06-20T17:16:53Z
dc.date.available2019-06-20T17:16:53Z
dc.date.issued2019
dc.degree.levelPh.Den_US
dc.description.abstractWe examine the maintenance and behavioural expression of long-term memories acquired in the absence of the hippocampus. The hypothesis that the hippocampus is necessary to form stable and detailed long-term memories is tested. We find rats with extensive hippocampal damage made before learning exhibit normal maintenance and behavioural expression of contextual fear memory, object discrimination, and context discrimination. The discovery that non-hippocampal networks can encode, maintain, and retrieve memories, widely-thought to be dependent on the hippocampus and its consolidation processes adds to a growing body of literature which draws into question most views of the hippocampus and memory consolidation. Our findings suggest: 1) hippocampal-dependent systems-level consolidation is not required for stable long-term memory in the rat; 2) non-hippocampal networks possess sufficient representational complexity to support normal discriminative memory-guided behaviours; 3) the broad distinction between hippocampal and non-hippocampal memories requires re-evaluation through rigorous experimentation, rather than adherence to modal views.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5423
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPsychobiology [0349]en_US
dc.proquest.subjectBehavioral sciences [0602]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectHippocampus (Brain)en_US
dc.subjectLong-term memoryen_US
dc.titleMaintenance and Behavioural Expression of Long-term Memories Acquired in the Absence of the Hippocampusen_US
dc.typeThesisen_US
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