Effects of maternal preconception stress on brain and behavior in male and female offspring

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dc.contributor.authorJenkins, Serena
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGibb, Robbin L.
dc.date.accessioned2017-10-20T15:55:57Z
dc.date.available2017-10-20T15:55:57Z
dc.date.issued2017
dc.degree.levelMastersen_US
dc.description.abstractBrain and behavior are shaped by experience. Stress during the preconception period is a new topic of interest, as it involves both prospective parents. The current study examined how maternal preconception stress impacts the development of offspring brain and behavior throughout the lifespan. Methods mirror those used in studies on paternal preconception stress, which allowed direct comparison between the effects on offspring when preconception stress is experienced by each parent. Female rats experienced stress for 27 days immediately prior to mating, and offspring completed a battery of behavioral tests beginning in early life and continuing into adulthood. Offspring brain was examined at weaning and in adulthood. Major findings include increased anxiety-like behavior, impaired working memory, deficits in fine motor control, decreased body weight, and reduced cortical thickness. Male offspring were disproportionately affected. Maternal preconception stress affects offspring similarly to stress at other times, but less severely than paternal preconception stress.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council Branch Out Neurological Foundationen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4944
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectmaternal preconception stressen_US
dc.subjectoffspring behavior developmenten_US
dc.subjectoffspring brain developmenten_US
dc.subjectpreconception stress effects on offspringen_US
dc.subjectstress researchen_US
dc.titleEffects of maternal preconception stress on brain and behavior in male and female offspringen_US
dc.typeThesisen_US
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