Low acetylcholine during early sleep is crucial for motor memory consolidation

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dc.contributor.authorQandeel
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2018-05-25T21:46:26Z
dc.date.available2018-05-25T21:46:26Z
dc.date.issued2018
dc.degree.levelMastersen_US
dc.description.abstractI investigated a potential relationship between motor memory and acetylcholine activity during early sleep characterized by slow-wave electroencephalographic activity and reduced cholinergic tone. I tested the hypothesis that altering acetylcholine levels during early sleep would disrupt motor memory consolidation. I trained 93 wild-type and 17 transgenic adult mice on motor tasks either rotarod or skilled-forelimb reach. Immediately after training, I either increased or decreased acetylcholine levels in the subsequent post-learning early sleep. Upon retesting performance on motor tasks, I discovered that increasing acetylcholine levels impaired motor memory consolidation while decreasing acetylcholine levels did not have an effect. I also found a larger involvement of muscarinic acetylcholine receptors compared to nicotinic ones for motor memory consolidation. With filming and electrophysiology, I determined that increasing acetylcholine altered sleep structure and reduced slow-wave activity in early sleep. These results suggest that motor memories are consolidated during slow-wave sleep when cholinergic levels are low.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5108
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0306en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectmotor memory consolidationen_US
dc.subjectsleepen_US
dc.subjectacetylcholine neuromodulationen_US
dc.subjectskilled forelimb reach tasken_US
dc.subjectrotarod tasken_US
dc.subjectelectrophysiologyen_US
dc.subjectAcetylcholineen_US
dc.subjectMemory consolidationen_US
dc.subjectSlow wave sleepen_US
dc.titleLow acetylcholine during early sleep is crucial for motor memory consolidationen_US
dc.typeThesisen_US
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