Metaplasticity : how experience during brain development influences the subsequent exposure to a drug of abuse

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dc.contributor.authorMuhammad, Arif
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2012-03-16T19:09:41Z
dc.date.available2012-03-16T19:09:41Z
dc.date.issued2011
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxii, 263 leaves : ill. ; 29 cmen_US
dc.description.abstractThe influence of experience during brain development was investigated on juvenile behavior, adult amphetamine sensitization, and neuronal structural plasticity in rats. Two experiential factors (i.e., tactile stimulation and stress) were studied either before or soon after birth. Early experience feminized social behavior in males; however, only stress enhanced anxiety-like behavior in males. Repeated amphetamine administration resulted in the development and persistence of behavioral sensitization. However, tactile stimulation attenuated the drug-induced behavioral sensitization whereas stress failed to influence the degree of sensitization. Neuroanatomical findings revealed that early experience altered the cortical and subcortical structures. Furthermore, drug exposure reorganized the brain structures involved in addiction but early experience prevented the drug-associated changes. Early adverse experience influences the subsequent exposure to a drug of abuse at anatomical level whereas a favorable experience has an effect both at behavioral and anatomical levels and thus may play a protective role against drug-induced sensitization and addiction.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2623
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrain -- Effect of drugs on -- Researchen_US
dc.subjectBrain -- Effect of stress on -- Researchen_US
dc.subjectBrain -- Adaptationen_US
dc.subjectPrefrontal cortex -- Effect of drugs on -- Researchen_US
dc.subjectPrefrontal cortex -- Effect of stress on -- Researchen_US
dc.subjectPrefrontal cortex -- Adaptationen_US
dc.subjectNucleus accumbens -- Effect of drugs on -- Researchen_US
dc.subjectNucleus accumbens -- Effect of stress on -- Researchen_US
dc.subjectNucleus accumbens -- Adaptationen_US
dc.subjectDevelopmental neurophysiologyen_US
dc.subjectNeuroplasticityen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleMetaplasticity : how experience during brain development influences the subsequent exposure to a drug of abuseen_US
dc.typeThesisen_US
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