Enhancing memory-related sleep spindles through learning and electrical brain stimulation

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dc.contributor.authorIyer, Kartik
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorEuston, David R.
dc.date.accessioned2022-04-28T17:11:17Z
dc.date.available2022-04-28T17:11:17Z
dc.date.issued2022
dc.degree.levelPh.Den_US
dc.description.abstractSleep has been strongly implicated in mediating memory consolidation through hippocampal-neocortical communication. Evidence suggests offline processing of encoded information in the brain during slow wave sleep (SWS), specifically during slow oscillations and spindles. In this work, we used active exploration and learning tasks to study post-experience sleep spindle density changes in rats. Experiences lead to subsequent changes in sleep spindles, but the strength and timing of the effect was task-dependent. Brain stimulation in humans and rats have been shown to enhance memory consolidation. However, the exact stimulation parameters which lead to the strongest memory enhancement have not been fully explored. We tested the efficacy of both cortical sinusoidal direct current stimulation and intracortical pulse stimulation to enhance slow oscillations and spindle density. Pulse stimulation reliably evoked state-dependent slow oscillations and spindles during SWS with increased hippocampal ripple-spindle coupling, demonstrating potential in memory enhancement.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6165
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Health Sciencesen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Health Sciences)en_US
dc.subjectlearning and memoryen_US
dc.subjectsleepen_US
dc.subjectspindlesen_US
dc.subjectelectrical brain stimulationen_US
dc.subjectSleep--Physiological aspectsen_US
dc.subjectMemory consolidation--Researchen_US
dc.subjectBrain stimulationen_US
dc.subjectSlow wave sleep--Researchen_US
dc.subjectBrain--Physiologyen_US
dc.subjectBrain--Electric propertiesen_US
dc.subjectCognitive neuroscienceen_US
dc.subjectLearning--Physiological aspectsen_US
dc.subjectMemory transfer--Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleEnhancing memory-related sleep spindles through learning and electrical brain stimulationen_US
dc.typeThesisen_US
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