Plasticity in the prefrontal cortex of adult rats
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Date
2015
Authors
Kolb, Bryan
Gibb, Robbin L.
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Abstract
We review the plastic changes of the prefrontal cortex of the rat in response to a
wide range of experiences including sensory and motor experience, gonadal hormones,
psychoactive drugs, learning tasks, stress, social experience, metaplastic experiences, and
brain injury. Our focus is on synaptic changes (dendritic morphology and spine density) in
pyramidal neurons and the relationship to behavioral changes. The most general conclusion
we can reach is that the prefrontal cortex is extremely plastic and that the medial and
orbital prefrontal regions frequently respond very differently to the same experience in the
same brain and the rules that govern prefrontal plasticity appear to differ for those of other
cortical regions.
Description
Sherpa Romeo green journal, open access
Keywords
Prefrontal cortex , Experience-dependent plasticity , Psychoactive drugs , Stress , Metaplasticity
Citation
Kolb, B., & Gibb, R. (2015). Plasticity in the prefrontal cortex of adult rats. Frontiers in Cellular Neuroscience, 9(15). doi:10.3389/fncel.2015.00015