Modulation of recovery and compensation after stroke

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dc.contributor.authorKirkland, Scott
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2007-07-20T19:52:17Z
dc.date.available2007-07-20T19:52:17Z
dc.date.issued2007
dc.degree.levelMasters
dc.descriptionxii, 122 leaves : ill. ; 29 cm.en
dc.description.abstractStress has been shown to exacerbate cell death and cognitive deficits after ischemic injury in rodents, however, little is known of the effects of stress on motor recovery. The objective of this present thesis is to examine the effects of chronic stress on skilled motor recovery after devascularization lesion in rats. It was found that pre-lesion stress induced the most behavioural impairments, while post-lesion stress exacerbated infarct volume. The effects of chronic multiple stress on skilled motor recovery after lesion was also examined. Chronic multiple stress did not modulate skilled motor recovery nor did it have any influence on infarct volume. Additionally, stress had effect on edema after devascularization lesion. The present thesis suggests that the time of exposure to chronic stress in respect to the ischemic lesion, in addition to the type of stress, will differentially affect recovery and compensation in rats.en
dc.identifier.urihttps://hdl.handle.net/10133/387
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007en
dc.publisher.departmentDepartment of Neuroscienceen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectCerebrovascular disease -- Animal modelsen
dc.subjectCerebrovascular disease -- Researchen
dc.subjectCerebrovascular disease -- Treatmenten
dc.subjectMotor ability -- Researchen
dc.subjectRats -- Effect of stress onen
dc.subjectRats as laboratory animalsen
dc.subjectStress (Physiology) -- Researchen
dc.titleModulation of recovery and compensation after strokeen
dc.typeThesisen
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