A Role of Epigenetics in Aging and the Age-Dependent Response to Ionizing Radiation

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dc.contributor.authorSidler, Corinne
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2014-10-03T20:14:52Z
dc.date.available2014-10-03T20:14:52Z
dc.date.issued2014-10-03
dc.degree.levelPh.Den_US
dc.description.abstractAging is associated with the functional decline of organs, and results in age-dependent differences in stress-sensitivity. Younger animals are more sensitive to mutagenic insults than adults, whereas in plants, the transition to reproductive growth is the most stress-sensitive. Here, we show a role of reduced H3K9 trimethylation and corresponding genomic instability in the aging rat thymus and in senescence of human fibroblasts. A similar reduction of SUV39H1 expression was observed in response to ionizing radiation (IR), which correlated with the induction of senescence. In plants exposed to IR during the transition to reproductive growth, histone methyltransferases were up-regulated, which correlated with reduced transcription of transposable elements. This difference in response may be reflected in the differences in life cycles. Whereas plants rely on the survival and genome integrity of meristematic cells for their reproductive success, in mammals, limiting the cell division in cells that have incurred damage may be crucial.en_US
dc.description.sponsorshipAlberta Innovates-Health Solutions, Alberta Cancer Foundation provided Graduate Studentshipsen_US
dc.identifier.urihttps://hdl.handle.net/10133/3508
dc.language.isoen_CAen_US
dc.proquest.subject0379en_US
dc.proquest.subject0307en_US
dc.proquest.subject0369en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences.
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyFaculty of Arts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectaging
dc.subjectgenomic instability
dc.subjecthistone methyltransferases
dc.subjecthuman fibroblasts
dc.subjectionizing radiation
dc.subjectlife cyces
dc.titleA Role of Epigenetics in Aging and the Age-Dependent Response to Ionizing Radiationen_US
dc.typeThesisen_US
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