Environmental and pharmacological intervention following cortical brain injury

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dc.contributor.authorHastings, Erica
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-05-01T14:19:28Z
dc.date.available2007-05-01T14:19:28Z
dc.date.issued2003
dc.degree.levelMasters
dc.descriptionxv, 177 leaves : ill. (some col.) ; 29 cm.en
dc.description.abstractThis thesis focuses on the effects of pharmacological and environmental interventions following perinatal prefrontal cortex lesions. Rats given postnatal day 3 medial prefrontal cortex lesions were provided with one of the following treatments: basic fibroblast growth factor (bFGF), complex-housing, tactile stimulation, or a combined treatment of both bFGF and tactile stimulation or bFGF and complex-housing. Rats given postnatal day 3 orbital prefrontal cortex lesions were housed in a complex environment. The findings of these studies suggest that bFGF, complex-housing or tactile stimulation are beneficial after early brain injury. The combined treatment of bFGF with complex-housing provides a synergistic effect, as the combined condition is more advantageous than bFGF alone. In contrast, the combined treatment of bFGF with tactile stimulation produced adverse effects. These results suggest that pharmacological and environmental manipulations change cortical plasticity and therefore functional recovery after neonatal cortical injury.en
dc.identifier.urihttps://hdl.handle.net/10133/180
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectBrain researchen
dc.subjectBrain -- Wounds and injuriesen
dc.subjectBrain -- Wounds and injuries -- Treatmenten
dc.subjectRats as laboratory animalsen
dc.titleEnvironmental and pharmacological intervention following cortical brain injuryen
dc.typeThesisen
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