Hippocampal neural representational dynamics: differential effects of visual information on place field directionality, position, and size

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dc.contributor.authorChekhov, Sergey
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughon, Bruce L.
dc.date.accessioned2020-07-30T15:54:25Z
dc.date.available2020-07-30T15:54:25Z
dc.date.issued2020
dc.degree.levelPh.Den_US
dc.description.abstractStored hippocampal spatial maps differ substantially from ones the hippocampus creates on initial acquaintance with a new environment. During the first few laps on a new maze, spatially tuned hippocampal ‘place cells’ develop an experience-dependent direction specificity and a backward shift of the place field centre of mass, normally associated with place field expansion. In this work, we used reliance on visual cues as a tool to test the putative functions and mechanisms of these three adjustments. We found that place field directionality was not affected by the availability of visual cues and therefore is not a primary mechanism to associate spatial and nonspatial information, as was previously hypothesized. Contrary to expectations, however, the place field expansion and backward shift appeared to be two distinct, independent phenomena with different reliance on visual cues. We propose new mechanisms for the observed phenomena taking into account their reliance on visual cues.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5744
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPhysiology [0719]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrainen_US
dc.subjectHippocampus (Brain)en_US
dc.subjectHippocampus (Brain) -- Physiologyen_US
dc.subjectMaze testsen_US
dc.subjectMemoryen_US
dc.subjectSpace perceptionen_US
dc.titleHippocampal neural representational dynamics: differential effects of visual information on place field directionality, position, and sizeen_US
dc.typeThesisen_US
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