Impacts of chronic and acute phase-shifting in male and female rats

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dc.contributor.authorZelinski, Erin L.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2012-01-24T17:14:08Z
dc.date.available2012-01-24T17:14:08Z
dc.date.issued2010
dc.descriptionxiv, 181 leaves : ill. (some col.) ; 29 cmen_US
dc.description.abstractThis thesis assessed the impacts of acute and chronic phase-shifting on learning and memory in male and female rats. Previous research has revealed impaired retention immediately following circadian disruption and on the acquisition of new associations. However, whether behaviour resumes normality following circadian re-entrainment is unresolved. Following circadian re-entrainment, retention of pre-phase-shift acquired associations on Morris water task (MWT) and a visual discrimination task designed on the 8-arm radial maze were tested. Subsequently, an extradimensional set shift (EDS) using the 8-arm radial maze was performed. Acute circadian disruption negatively impacted retention in males and females, but only male rats without running wheels exhibited impairment following chronic phase-shifting on MWT performance. Retention on the visual discrimination task was impaired following chronic, but not acute, circadian disruption. Chronic, but not acute, phase-shifting negatively impacted performance on the EDS. Generally, phase-shifting produced differential negative impacts on cognitive function in rats.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2590
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2010en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCircadian rhythms -- Researchen_US
dc.subjectSuprachiasmatic nucleus -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleImpacts of chronic and acute phase-shifting in male and female ratsen_US
dc.typeThesisen_US
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