Transgenerational programming of maternal behaviour by prenatal stress

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dc.contributor.authorWard, Isaac D.
dc.contributor.authorZucchi, Fabiola C.R.
dc.contributor.authorRobbins, Jerrah C.
dc.contributor.authorFalkenberg, Erin A.
dc.contributor.authorOlson, David M.
dc.contributor.authorBenzies, Karen
dc.contributor.authorMetz, Gerlinde A. S.
dc.date.accessioned2018-06-01T17:16:36Z
dc.date.available2018-06-01T17:16:36Z
dc.date.issued2013
dc.descriptionSherpa Romeo green journal. Open access, distributed under the terms of the Creative Commons Attribution (CC-BY) Licenseen_US
dc.description.abstractPeripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in rat maternal behaviour as a function of gestational and prenatal stress. Pregnant dams of the parental generation were exposed to stress from days 12-18 (F0-S). Their daughters and grand-daughters were either stressed (F1-SS, F2-SSS) or non-stressed (F1-SN, F2-SNN). Maternal antepartum behaviours were analyzed at a time when pregnant dams usually show a high frequency of tail chasing behaviours. F1-SS, F2-SNN and F2-SSS groups showed a significant reduction in tail chasing behaviours when compared with controls. The effects of multigenerational stress (SSS) slightly exceeded those of transgenerational stress (SNN) and resulted in absence of tail chasing behaviour. These findings suggest that antepartum maternal behaviour in rats is programmed by transgenerational inheritance of stress responses. Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationWard, I.D., Zucchi, F.C.R., Robbins, J.C., Falkenberg, E.A., Olson, D.M., Benzies, K., & Metz, G.A. (2013). Transgenerational programming of maternal behaviour by prenatal stress. BMC Pregnancy & Childbirth, 13(Suppl 1), 59. doi:10.1186/1471-2393--13-S1-S9en_US
dc.identifier.urihttps://hdl.handle.net/10133/5118
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionUniversity of Albertaen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectPrenatal stressen_US
dc.subjectMaternal behaviouren_US
dc.subjectMultigenerational stressen_US
dc.subjectTransgenerational stressen_US
dc.subjectTail chasing behaviouren_US
dc.subjectRatsen_US
dc.subjectStress responseen_US
dc.subjectGestationen_US
dc.subject.lcshRats--Behavior
dc.subject.lcshRats--Pregnancy
dc.titleTransgenerational programming of maternal behaviour by prenatal stressen_US
dc.typeArticleen_US
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