The effect of psilocybin and eugenol in dextran and lipopolysaccharide induced gastro-intestinal inflammation

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dc.contributor.authorAsghari, Zeinab
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.contributor.supervisorKovalchuk, Igor
dc.date.accessioned2024-03-25T15:19:48Z
dc.date.available2024-03-25T15:19:48Z
dc.date.issued2023
dc.degree.levelMasters
dc.description.abstractInflammatory bowel disease (IBD) is a complex gastrointestinal condition, arising from immune dysfunction, epithelial cell abnormalities, and gut microbiota imbalances. This study seeks to find the potential anti-inflammatory properties of psilocybin and eugenol in both local and systemic intestinal inflammation by utilizing a murine model of IBD induced by dextran sulfate sodium (DSS) and lipopolysaccharide (LPS). We evaluated the impact of these compounds on inflammatory cytokine levels in intestinal tissues and also explored changes in serotonin receptor (HTR2A and B) expression, and transient receptor potential (TRP) ion channels (TRP1 and TRPM8), analyzing the influence of these compounds on serotonin signaling pathways. Our study yielded significant insights into the multifaceted world of inflammation within the gastrointestinal tract. Notably, our findings revealed intriguing disparities in the trends observed pre- and post-treatment, particularly in the context of small and large intestine inflammation induced by LPS and DSS. Additionally, our study unearthed evidence of the anti-inflammatory properties of psilocybin and eugenol, compounds with agonistic effects on serotonin and TRP channels. Most notably, we observed a synergistic effect when these compounds were combined. More comprehensive studies on the medicinal effects of natural compounds in IBD animal models are pivotal for exploring their implications, specifically the analysis of drug-microbiota-immune system interactions.
dc.embargoNo
dc.identifier.urihttps://hdl.handle.net/10133/6728
dc.language.isoen
dc.proquest.subject0306
dc.proquest.subject0307
dc.proquest.subject0719
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
dc.publisher.departmentDepartment of Biological Sciences
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectinflammatory bowel disease
dc.subjectpsilocybin
dc.subjecteugenol
dc.subjectanti-inflammatories
dc.subjectdextran sulfate sodium model
dc.subjectlipopolysaccharide model
dc.subject.lcshInflammatory bowel diseases--Research
dc.subject.lcshInflammatory bowel diseases--Treatment--Research
dc.subject.lcshInflammatory bowel diseases--Animal models
dc.subject.lcshPsilocybin--Research
dc.subject.lcshPsilocybin--Therapeutic use--Research
dc.subject.lcshEugenol--Research
dc.subject.lcshEugenol--Therapeutic use--Research
dc.subject.lcshAnti-inflammatory agents--Research
dc.subject.lcshInflammation--Animal models
dc.subject.lcshMice as laboratory animals
dc.subject.lcshDissertations, Academic
dc.titleThe effect of psilocybin and eugenol in dextran and lipopolysaccharide induced gastro-intestinal inflammation
dc.typeThesis
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