Examining the effects of deep brain stimulation and targeted memory reactivation on rodent motor learning

Simple item page
dc.contributor.authorCampbell, Seth Y.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorTatsuno, Masami
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2023-05-16T19:40:02Z
dc.date.available2023-05-16T19:40:02Z
dc.date.issued2023
dc.degree.levelMasters
dc.description.abstractOne important form of memory that is enhanced through repeated training and sleep are motor memories. Motor memories play a vital role in many physical movements and skills we make. Despite this, our understanding of how these memories are processed and enhanced during sleep is not completely understood. Two techniques for sleep manipulation have been proposed to possibly help improve learning: deep brain stimulation (DBS) and targeted memory reactivation (TMR). This work tested whether a combination of these two techniques could improve the rate of learning in a pellet reaching task using rats. Four experimental rats who received DBS and TMR and two control rats were implanted with local field potential (LFP) electrodes and trained on the single-pellet reaching task for 15 days total, accompanied by rest before and after. Although DBS did increase the rate of spindles occurring in experimental rats, there was no performance difference in the task between groups. Sharp wave-ripple events did not significantly differ between groups, but spindle onset relative to DBS pulse peri-event histogram showed a significant increase at the 100-300ms range, supporting a previous study (Eckert et al., 2021). Follow-up pilot studies were conducted to further improve the original experiment’s design as well, but no follow-up study design could be confirmed yet. Future directions are discussed including possible changes to stimulation paradigms, experiment design and using an alternative motor learning task.
dc.identifier.urihttps://hdl.handle.net/10133/6493
dc.proquest.subject0317
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectMotor memory
dc.subjectDeep brain stimulation
dc.subjectTargeted memory reactivation
dc.subjectRate of learning
dc.subjectReaching task
dc.subjectMotor learning task
dc.subject.lcshMotor learning
dc.subject.lcshMovement, Psychology of
dc.subject.lcshDissertations, Academic
dc.titleExamining the effects of deep brain stimulation and targeted memory reactivation on rodent motor learning
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CAMPBELL_SETH_MSC_2023.pdf
Size:
1.92 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses