Neural basis of proximal influences on choice: recent reinforcement, inter-trial interval, and uncertainty

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dc.contributor.authorThapa, Rajat
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGruber, Aaron J.
dc.date.accessioned2018-07-27T21:11:05Z
dc.date.available2018-07-27T21:11:05Z
dc.date.issued2018
dc.degree.levelPh.Den_US
dc.description.abstractDescribing how animals make decisions is fundamental to understanding animal behaviour. Here we describe the transient yet significant influence of recent wins and losses on subsequent decisions in a competitive two-choice paradigm. We report that the drive to shift to alternate choices after a loss (lose-shift response) decays monotonically within the first few seconds of the inter-trial interval whereas the tendency to repeat a choice after a win (win-stay response) is initially low, gradually increases for few seconds, and then declines. We also show that the level of contextual uncertainty is correlated with the number of exploratory responses observed in the operant chamber. Furthermore, we report that lose-shift is dependent on the integrity of the ventrolateral striatum whereas win-stay is dependent on proper phasic dopaminergic signalling in the ventromedial striatum. Overall, our results suggest that lose-shift and win-stay response depend on dissociable circuits within the ventral striatum.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5176
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0384en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectRaten_US
dc.subjectDecision-makingen_US
dc.subjectStriatumen_US
dc.subjectReinforcement learningen_US
dc.subjectLateral Habenulaen_US
dc.subjectDecision making in animalsen_US
dc.subjectReward (Psychology)en_US
dc.subjectReinforcement (Psychology)en_US
dc.subjectBrain -- Localization of functionsen_US
dc.titleNeural basis of proximal influences on choice: recent reinforcement, inter-trial interval, and uncertaintyen_US
dc.typeThesisen_US
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