Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: whispers in silence

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dc.contributor.authorFaraji, Jamshid
dc.contributor.authorSoltanpour, Nabiollah
dc.contributor.authorMoeeini, Reza
dc.contributor.authorRoudaki, Shabnam
dc.contributor.authorSoltanpour, Nasrin
dc.contributor.authorAbdollahi, Ali-Akbar
dc.contributor.authorMetz, Gerlinde A. S.
dc.date.accessioned2016-08-17T18:24:31Z
dc.date.available2016-08-17T18:24:31Z
dc.date.issued2014
dc.descriptionOpen access journalen_US
dc.description.abstractSilent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal functions especially vulnerable to ischemiainduced deficits. The present study investigated whether an otherwise silent ischemic mini infarct in the hippocampus (HPC) can produce impairments in spatial performance in rats. Spatial performance was assessed in the ziggurat task (ZT) using a 10-trial spatial learning protocol for 4 days prior to undergoing hippocampal ischemic lesion or sham surgery. Hippocampal silent ischemia was induced by infusion of endothelin-1 (ET-1), a potent vasoconstrictor, into either the dorsal or the ventral hippocampus (dHPC and vHPC). When tested postoperatively in the ZT using a standard testing protocol for 8 days, rats with hippocampal lesions exhibited no spatial deficit. Although spatial learning and memory in the ZT were not affected by the ET-1-induced silent ischemia, rats with dHPC stroke showed more returns when navigating the ZT as opposed to the vHPC rats. Comparison of region-specific HPC lesions in the present study indicated that dorsal hippocampal function is critically required for topographic orientation in a complex environment. Topographic disorientation as reflected by enhanced return behaviors may represent one of the earliest predictors of cognitive decline after silent ischemic insult that may be potentially traced with sensitive clinical examination in humans.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationFaraji, J., Soltanpour, N., Moeeini, R., Roudaki, S., Soltanpour, N., Abdollahi, A., & Metz, G. A. S. (2014). Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: whispers in silence. Frontiers in Behavioral Neuroscience, 8, 261. doi:10.3389/fnbeh.2014.00261en_US
dc.identifier.urihttps://hdl.handle.net/10133/4587
dc.language.isoen_CAen_US
dc.publisherFrontiers Research Foundationen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionGolestan University of Medical Sciencesen_US
dc.publisher.institutionBabol University of Medical Sciencesen_US
dc.publisher.institutionAvicenna Institute of Neuroscienceen_US
dc.subjectSilent strokeen_US
dc.subjectEndotelin-1en_US
dc.subjectHippocampusen_US
dc.subjectZiggurat tasken_US
dc.subjectReturn behavioren_US
dc.subjectSpatial navigationen_US
dc.subjectTopographical disorientationen_US
dc.subjectEarly cognitive declineen_US
dc.titleTopographical disorientation after ischemic mini infarct in the dorsal hippocampus: whispers in silenceen_US
dc.typeArticleen_US
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