Radiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRae

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dc.contributor.authorMcRae, Dorothy A.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2012-02-24T19:11:14Z
dc.date.available2012-02-24T19:11:14Z
dc.date.issued2010
dc.degree.levelMasters
dc.descriptionxi, 120 leaves ; 29 cmen_US
dc.description.abstractMost breast cancer patients undergo radiation diagnostics and are also treated with radiotherapy. In addition to being an important treatment modality, ionizing radiation (IR) is a potent tumour-causing agent that has been linked to breast cancer development. However, the exact molecular etiology of IR-induced mammary gland carcinogenesis remains unknown. We set out to analyze the role of DNA methylation in mammary gland responses to low dose IR using a well-established rat model. We also studied low dose IR effects on global gene expression and microRNAome. We found that exposure to low, mammography-like dose of IR led to a significant loss of global DNA methylation in rat mammary gland tissue. Furthermore, low dose IR significantly affected rat mammary gland transcriptome and microRNAome. The datasets generated within the scope of this thesis may be used to identify novel predictive biomarkers for assessment of the magnitude of IR effects on mammary gland tissue.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2615
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectIonizing radiation -- Health aspectsen_US
dc.subjectIonizing radiation -- Physiological effecten_US
dc.subjectIonizing radiation -- Dose-response relationshipen_US
dc.subjectDNA -- Methylationen_US
dc.subjectBreast -- Cancer -- Radiotherapyen_US
dc.subjectDissertations, Academicen_US
dc.titleRadiation induced epigenetic dysregulation in rat mammary gland tissue / Dorothy A. McRaeen_US
dc.typeThesisen_US
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