The effects of Cannabis sativa extracts on melanoma cancer cells in vitro

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dc.contributor.authorRostamian, Yasaman
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2022-06-09T18:16:55Z
dc.date.available2022-06-09T18:16:55Z
dc.date.issued2022
dc.degree.levelMastersen_US
dc.description.abstractMelanoma is the deadliest form of skin cancer, and its mortality continues to rise. Although early diagnosis and development of new treatments have improved melanoma prognosis, many patients develop resistance to current therapies. Research demonstrates that the main active ingredients of the cannabis plant, cannabinoids, have potential anti-cancer effects in different models of cancer. Cannabis plants, however, contain more than 545 secondary metabolites, which have shown to have medicinal potential and are believed to create an entourage effect when used together. The current study explores the anti-proliferative effects of ten cannabis extracts on melanoma cells in vitro. We discovered that studied cannabis extracts are cytotoxic for melanoma cells in a time- and dose-dependent manner and that high THC cannabis extracts exert higher cytotoxicity compared to their corresponding amount of THC alone. This anti-tumor activity may be via regulation of MAPK/ERK and PI3K/AKT pathway.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6244
dc.language.isoen_USen_US
dc.proquest.subject0379en_US
dc.proquest.subject0369en_US
dc.proquest.subject0307en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. :University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCannabis sativaen_US
dc.subjectCannabis extracts
dc.subjectMelanoma cells
dc.subject.lcshCannabis--Therapeutic use
dc.subject.lcshMelanoma
dc.subject.lcshSkin--Cancer--Treatment
dc.subject.lcshDissertations, Academic
dc.titleThe effects of Cannabis sativa extracts on melanoma cancer cells in vitroen_US
dc.typeThesisen_US
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