Cortico-cortical and hippocampal-cortical interactions in mouse models of Alzheimer’s disease

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dc.contributor.authorSingh, Surjeet
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2021-11-22T22:34:41Z
dc.date.available2021-11-22T22:34:41Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractAlzheimer’s disease (AD) is a neurodegenerative disease which is pathologically characterized by extracellular deposition of amyloid beta (Aβ) plaques, intracellular deposition of neurofibrillary tangles (NFT) caused by hyperphosphorylated tau protein, neuroinflammation, and progressive neuron loss. Brain regions involved in memory processing, such as hippocampus and the neocortex, are affected in the early stages of disease pathology. Using in vivo mesoscale wide-field voltage imaging and local field potential (LFP) recording from CA1 region of the hippocampus in 6- and 12-month-old (1) knock-in (AppNL-G-F) and (2) transgenic (5xFAD) mouse model of AD, this study is aimed at understanding how cortico-cortical and hippocampal-cortical interactions are affected by AD. Aberrant sensory evoked cortical activity and resting state cortical functional connectivity were observed in AD and sharp wave ripples (SWRs), which subserve important aspects of hippocampal-cortical interactions are disrupted in AD. Further, gradual cerebral hypoperfusion exacerbate AD pathology and network dysfunctions.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6094
dc.language.isoenen_US
dc.proquest.subject0317en_US
dc.proquest.subject0571en_US
dc.proquest.subject0719en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectneuroscienceen_US
dc.subjectneurobiologyen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectmemory processing brain regionsen_US
dc.subjectcortico-cortical interactionsen_US
dc.subjecthippocampal-cortical interactionsen_US
dc.subjectAlzheimer's disease -- Researchen_US
dc.subjectAlzheimer's disease -- Pathophysiologyen_US
dc.subjectAlzheimer's disease -- Animal modelsen_US
dc.subjectMice as laboratory animalsen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurobiologyen_US
dc.subjectHippocampus (Brain) -- Researchen_US
dc.subjectNeocortex -- Researchen_US
dc.subjectAmyloid beta-proteinen_US
dc.subjectNeural networks (Neurobiology) -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleCortico-cortical and hippocampal-cortical interactions in mouse models of Alzheimer’s diseaseen_US
dc.typeThesisen_US
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