Allostatic load and preterm birth

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dc.contributor.authorOlson, David M.
dc.contributor.authorSeverson, Emily M.
dc.contributor.authorVerstraeten, Barbara S. E.
dc.contributor.authorNg, Jane W. Y.
dc.contributor.authorMcCreary, J. Keiko
dc.contributor.authorMetz, Gerlinde A. S.
dc.date.accessioned2016-07-28T00:31:28Z
dc.date.available2016-07-28T00:31:28Z
dc.date.issued2015
dc.descriptionOpen accessen_US
dc.description.abstractPreterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women will actually deliver. Until these problems are addressed, there will be no interventions to reduce the risk because those who should be treated will not be known. Considerable evidence now exists that chronic life, generational or accumulated stress is a risk factor for preterm delivery in animal models and in women. This wear and tear on the body and mind is called allostatic load. This review explores the evidence that chronic stress contributes to preterm birth and other adverse pregnancy outcomes in animal and human studies. It explores how allostatic load can be used to, firstly, model stress and preterm birth in animal models and, secondly, how it can be used to develop a predictive model to assess relative risk among women in early pregnancy. Once care providers know who is in the highest risk group, interventions can be developed and applied to mitigate their risk.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationOlson, D. M., Severson, E. M., Verstraeten, B. S. E., Ng, J. W. Y., McCreary, J. K., & Metz, G. A. S. (2015). Allostatic load and preterm birth. International Journal of Molecular Sciences, 16, 29856-29874. doi:10.3390/ijms161226209en_US
dc.identifier.urihttps://hdl.handle.net/10133/4560
dc.language.isoen_CAen_US
dc.publisherM D P I A Gen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Albertaen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectAllostatic loaden_US
dc.subjectAllostasisen_US
dc.subjectChronic stressen_US
dc.subjectPreterm birthen_US
dc.subjectInflammationen_US
dc.subjectTwo hitsen_US
dc.subjectMultiple hit hypothesisen_US
dc.subjectAdverse pregnancy outcomesen_US
dc.titleAllostatic load and preterm birthen_US
dc.typeArticleen_US
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