Distribution of sleep structure is maintained, but adjusted in an acute circadian shift: a study by continuous long-term local field potential recording

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dc.contributor.authorRota, Ryan Y.
dc.contributor.supervisorMasami, Tatsuno
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2014-10-03T20:17:58Z
dc.date.available2014-10-03T20:17:58Z
dc.date.issued2014-10-03
dc.degree.levelMastersen_US
dc.description.abstractEvidence suggests that the disruption of circadian rhythms has a negative impact on memory retention. It is therefore speculated that circadian disruption influences some property of sleep responsible for memory retention, but little is known about this relationship. In order to investigate this question, we have continuously recorded local field potentials in the hippocampus and prefrontal cortex of freely behaving adult male Long Evans rats. The current analysis indicates that daily quantities of sleep are strongly maintained in an acute circadian shift. Furthermore, hourly sleep distributions are largely maintained during the shift. Contrastingly, an acute circadian shift is able to alter the hourly distribution of vigilance states and sleep based events predominantly across pre-entrainment to post-entrainment, supporting previous findings of memory retention deficits observed during post-entrainment but not shifting epochs. Furthermore, current analysis suggests that pre-entrainment hourly distributions are conserved, but relocated in phase with post-entrainment.en_US
dc.description.sponsorshipNSERC, AIHSen_US
dc.identifier.urihttps://hdl.handle.net/10133/3512
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquest.subject0308en_US
dc.proquest.subject0544en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience.
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectNeuroscienceen_US
dc.subjectSleep structureen_US
dc.subjectCircadian disruptionen_US
dc.subjectLocal field potentialen_US
dc.subjectmemory retention
dc.subjectsleep
dc.titleDistribution of sleep structure is maintained, but adjusted in an acute circadian shift: a study by continuous long-term local field potential recordingen_US
dc.typeThesisen_US
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