Behavioural influences on the stability of points with optogenetic stimulation of motor cortices

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dc.contributor.authorMirza Agha, Behroo
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWhishaw, Ian Q.
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2023-10-13T16:28:40Z
dc.date.available2023-10-13T16:28:40Z
dc.date.issued2023
dc.degree.levelPh.D
dc.description.abstractThis thesis investigates the stability of points on the motor cortex of the mouse produced using optogenetic stimulation. Mice were implanted with fiber optic probes in four areas of the motor cortex and one in a non-motor area for control. They received stimulation of various frequency and duration as they engaged in six different voluntary and automatic behaviour. Control stimulation was also administered via a separate optic probe located on the side of the apparatus. The general findings are that the outcome of the stimulation depends on the ongoing behaviour of the mouse at the time of stimulation. Thus, stimulation effects are unstable, and behaviour is a contributing factor.
dc.identifier.urihttps://hdl.handle.net/10133/6603
dc.language.isoen
dc.proquest.subject0317
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectstability of points
dc.subjectmotor cortex
dc.subjectoptogenetic stimulation
dc.subjectbehavioural influences
dc.subject.lcshMotor cortex--Research
dc.subject.lcshBrain stimulation--Research
dc.subject.lcshMice as laboratory animals
dc.subject.lcshMice--Behavior
dc.subject.lcshMovement sequences--Research
dc.subject.lcshOptogenetics
dc.subject.lcshNeurosciences
dc.subject.lcshDissertations, Academic
dc.titleBehavioural influences on the stability of points with optogenetic stimulation of motor cortices
dc.typeThesis
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