The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations

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dc.contributor.authorKesler, Mitchell T.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2017-03-06T18:04:00Z
dc.date.available2017-03-06T18:04:00Z
dc.date.issued2016
dc.degree.levelMastersen_US
dc.description.abstractCortico-hippocampal communication is critical for cognitive processes including behavioural flexibility, and memory formation, consolidation, and retrieval. Nucleus reuniens of the thalamus has been implicated in memory consolidation. Consolidation involves the reactivation of hippocampal ensembles with neocortical memory traces to convert episodic memories to semantic knowledge and is believed to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and SPWRs. While previous studies have demonstrated effective local neural inactivation using lidocaine dialysis, I did not observe any effects that could be used to positively verify a drug effect. The data thus tentatively provide evidence that reuniens does not coordinate KSs and SPWRs. Future studies will be needed using methods for which inactivation can be positively identified.en_US
dc.description.sponsorshipAIHS (Polaris Award)en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4790
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0989en_US
dc.proquest.subject0719en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectKCsen_US
dc.subjectlidocaine dialysisen_US
dc.subjectmedioventral nucleusen_US
dc.subjectmemory consolidationen_US
dc.subjectmPFCen_US
dc.subjectSPWRsen_US
dc.titleThe effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlationsen_US
dc.typeThesisen_US
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