Exploring the epigenetic link in circadian disruption induced breast cancer

Simple item page
dc.contributor.authorKochan, David
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2015-05-05T16:30:30Z
dc.date.available2015-05-05T16:30:30Z
dc.date.issued2015
dc.degree.levelMastersen_US
dc.description.abstractBreast cancer is the leading cause of cancer-related death among women worldwide. Evidence is also mounting that circadian disruption (CD) is probably carcinogenic to humans and is linked to breast cancer development. The aim of this thesis is to provide new insights into the epigenetic links involved in CD-induced breast cancer. The results presented here show for the first time that CD induces expression changes in breast cancer-relevant and potentially circadian-relevant miRNAs in mammary tissues. Moreover, the results also show that long-term CD can potentially cause gene expression changes on a large enough scale to influence breast cancer-relevant signaling pathways. These findings align with previous studies that have shown that CD is a warranted concern in breast cancer development, and that the initiation of this process may be linked to aberrant CD-induced miRNA activity in the mammary tissues.en_US
dc.description.sponsorshipCanadian Breast Cancer Foundationen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3673
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectbreast canceren_US
dc.subjectcircadian disruptionen_US
dc.subjectepigeneticsen_US
dc.subjectmiRNAsen_US
dc.titleExploring the epigenetic link in circadian disruption induced breast canceren_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
KOCHAN_DAVID_MSC_2015.pdf
Size:
3.09 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses