The role of epigenetics in the rat mammary gland

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dc.contributor.authorKutanzi, Kristy
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2011-08-08T20:27:14Z
dc.date.available2011-08-08T20:27:14Z
dc.date.issued2010
dc.degree.fieldArts and Sciences
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.descriptionxiv, 190 leaves : ill. (chiefly col.) ; 29 cmen_US
dc.description.abstractEpigenetics plays an important role in carcinogenesis with heritable changes in DNA methylation and histone modifications intricately linked to the initiation, promotion, and progression of cancer. Evidence shows that a number of chemical and physical agents can induce epigenetic changes during carcinogenesis. Two such agents, estrogen and ionizing radiation, are generally recognized as being carcinogenic. Yet the epigenetic repercussions of these carcinogens remain relatively unknown. More importantly, the combined effect of these carcinogens has never been addressed in vivo from an epigenetic standpoint. Therefore, we focused on the effect of estrogen and ionizing radiation applied separately or in conjunction. We have found that the exposure to estrogen, either alone or in combination with radiation, induced pronounced morphological alterations, which was paralleled by modifications to the epigenomic landscape in the mammary gland. The results obtained from these rodent models can potentially be extrapolated to humans.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2492
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCarcinogenesisen_US
dc.subjectEstrogenen_US
dc.subjectIonizing radiationen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectEpigenesisen_US
dc.subjectMammary glands -- Canceren_US
dc.subjectBreast -- Cancer -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleThe role of epigenetics in the rat mammary glanden_US
dc.typeThesisen_US
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