The effect of pathogens on plant genome stability

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dc.contributor.authorFilkowski, Jody
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Igor
dc.date.accessioned2007-05-17T14:48:37Z
dc.date.available2007-05-17T14:48:37Z
dc.date.issued2004
dc.degree.levelMasters
dc.descriptionxiii, 119 leaves ; 29 cm.en
dc.description.abstractResistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition may have arisen through frequent genetic rearrangements as a result of transient, reduced genome stability. Tabacco plants transgenic for a recombination construct exhibited reduced genome stability upon infection with a virulent pathogen (tobacco mosaic virus). The reduced genome stability manifested as an increase in recombination events in the transgene. Such increases were observed following a virulent pathogen attack. This increase in recombination was shown to be systemic and was observed prior to systemic viral movement suggesting the presence of a systemic recombination signal. Further molecular analyses revealed that specific R-gene loci experience a large frequency of rearrangements following a virulent pathogen encounter. The possible targeting of instability to R-gene regions may be controlled through epigenetic processes, in particular, DNA methylation.en
dc.identifier.urihttps://hdl.handle.net/10133/254
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2004en
dc.publisher.departmentDepartment of Biological Sciences
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectPlants -- Disease and pest resistance -- Genetic aspectsen
dc.subjectPlant diseases -- Genetic aspectsen
dc.subjectPlant molecular geneticsen
dc.titleThe effect of pathogens on plant genome stabilityen
dc.typeThesisen
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