The effect of pathogens on plant genome stability
dc.contributor.author | Filkowski, Jody | |
dc.contributor.author | University of Lethbridge. Faculty of Arts and Science | |
dc.contributor.supervisor | Kovalchuk, Igor | |
dc.date.accessioned | 2007-05-17T14:48:37Z | |
dc.date.available | 2007-05-17T14:48:37Z | |
dc.date.issued | 2004 | |
dc.degree.level | Masters | |
dc.description | xiii, 119 leaves ; 29 cm. | en |
dc.description.abstract | Resistance (R) genes, a key factor in determining the resistance of plants, have been shown often to be highly allelic entities existing in duplicated regions of the genome. This characteristic suggests that R-gene acquisition may have arisen through frequent genetic rearrangements as a result of transient, reduced genome stability. Tabacco plants transgenic for a recombination construct exhibited reduced genome stability upon infection with a virulent pathogen (tobacco mosaic virus). The reduced genome stability manifested as an increase in recombination events in the transgene. Such increases were observed following a virulent pathogen attack. This increase in recombination was shown to be systemic and was observed prior to systemic viral movement suggesting the presence of a systemic recombination signal. Further molecular analyses revealed that specific R-gene loci experience a large frequency of rearrangements following a virulent pathogen encounter. The possible targeting of instability to R-gene regions may be controlled through epigenetic processes, in particular, DNA methylation. | en |
dc.identifier.uri | https://hdl.handle.net/10133/254 | |
dc.language.iso | en_US | en |
dc.publisher | Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2004 | en |
dc.publisher.department | Department of Biological Sciences | |
dc.publisher.faculty | Arts and Science | |
dc.relation.ispartofseries | Thesis (University of Lethbridge. Faculty of Arts and Science) | en |
dc.subject | Dissertations, Academic | en |
dc.subject | Plants -- Disease and pest resistance -- Genetic aspects | en |
dc.subject | Plant diseases -- Genetic aspects | en |
dc.subject | Plant molecular genetics | en |
dc.title | The effect of pathogens on plant genome stability | en |
dc.type | Thesis | en |