Adenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen-purine linkage in the differential global genomic repair propensity

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dc.contributor.authorKathuria, Preetleen
dc.contributor.authorSharma, Purshotam
dc.contributor.authorWetmore, Stacey D.
dc.date.accessioned2017-03-01T00:13:15Z
dc.date.available2017-03-01T00:13:15Z
dc.date.issued2015
dc.descriptionSherpa Romeo green journal: open accessen_US
dc.description.abstractComputational modeling is employed to provide a plausible structural explanation for the experimentally-observed differential global genome repair (GGR) propensity of the ALII-N2-dG and ALIIN6- dA DNA adducts of aristolochic acid II. Our modeling studies suggest that an intrinsic twist at the carcinogen–purine linkage of ALII-N2-dG induces lesion site structural perturbations and conformational heterogeneity of damaged DNA. These structural characteristics correlate with the relative repair propensities of AA-adducts, where GGR recognition occurs for ALII-N2-dG, but is evaded for intrinsically planar ALII-N6-dA that minimally distorts DNA and restricts the conformational flexibility of the damaged duplex. The present analysis on the ALII adduct model systems will inspire future experimental studies on these adducts, and thereby may extend the list of structural factors that directly correlate with the propensity for GGR recognition.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationKathuria, P., Sharma, P., & Wetmore, S. D. (2015). Adenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen-purine linkage in the differential global genomic repair propensity. Nucleic Acids Research, (43(15), 7388-7397. doi:10.1093/narl/gkv701en_US
dc.identifier.urihttps://hdl.handle.net/10133/4787
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectComputational modelingen_US
dc.subjectAristolochic acidsen_US
dc.subjectGlobal genome repairen_US
dc.subjectCarcinogen-purine linkageen_US
dc.subjectDNAen_US
dc.subjectDNA adductsen_US
dc.titleAdenine versus guanine DNA adducts of aristolochic acids: role of the carcinogen-purine linkage in the differential global genomic repair propensityen_US
dc.typeArticleen_US
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