Urinary and blood-derived biomarkers indicative of recovery from traumatic brain injury and spinal cord injury

Simple item page
dc.contributor.authorBykowski, Elani Ann
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.contributor.supervisorMontina, Tony
dc.date.accessioned2020-05-29T21:10:37Z
dc.date.available2020-05-29T21:10:37Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractBackground: This study aims to determine if a proton nuclear magnetic resonance-based quantitative metabolic profiling approach can identify novel biomarkers in clinically accessible biofluids that are indicative of both the repair processes and treatment efficacy during recovery from traumatic brain injury and spinal cord injury. The main hypotheses of this study are (a) that changes in the metabolic profiles following injury can be correlated to the extent of recovery of patients and (b) that biological pathway analysis will provide an insight into the mechanisms behind the repair process. Methods: Patients with spinal cord injury and traumatic brain injury were recruited through the Foothills Medical Centre in Calgary, Alberta. Urine and blood samples were collected from patients initially and again at 6 months post-injury for NMR spectral acquisition. Impact: Metabolomic analysis provides a window into the pathophysiological processes that underlie the recovery process, with insight for clinical application.en_US
dc.description.sponsorshipCanadian Institute of Health Researchen_US
dc.identifier.urihttps://hdl.handle.net/10133/5734
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0382en_US
dc.proquest.subject0719en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectMetabolomicsen_US
dc.subjectNuclear Magnetic Resonance Spectroscopyen_US
dc.subjectBiomarkersen_US
dc.subjectBrain -- Wounds and injuriesen_US
dc.subjectSpinal cord -- Wounds and injuriesen_US
dc.subjectBiochemical markersen_US
dc.subjectMagnetic resonance imaging -- Diagnostic useen_US
dc.subjectBlood -- Analysisen_US
dc.subjectUrine -- Analysisen_US
dc.subjectMetabolites -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleUrinary and blood-derived biomarkers indicative of recovery from traumatic brain injury and spinal cord injuryen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BYKOWSKI_ELANI_MSC_2020.pdf
Size:
1.82 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses