Biological Sciences

 

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  • Bressler, Kamiko R.; Ross, Joseph A.; Ilnytskyy, Slava; Vanden Dungen, Keiran; Taylor, Katrina; Patel, Kush; Zovoilis, Athanasios; Kovalchuk, Igor; Thakor, Nehal (SpringerArts and ScienceDepartment of Chemistry and BiochemistryDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1007/s12192-020-01174-1, 2020)
    During the integrated stress response (ISR), global translation initiation is attenuated; however, noncanonical mechanisms allow for the continued translation of specific transcripts. Eukaryotic initiation factor 5B (eIF5B) ...
  • Lari, Ebrahim (Arts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2020)
    Diltiazem is ubiquitously prescribed and has been reported in many effluents and freshwater bodies. Being a calcium channel blocker, diltiazem could disrupt the function of the sensory and central nervous systems. In the ...
  • McCreary, J. Keiko; Erickson, Zachary T.; Hao, XongXin; Ilnytskyy, Yaroslav; Kovalchuk, Igor; Metz, Gerlinde A. S. (Nature ResearchArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of Lethbridgehttps://doi.org/10.1038/srep37814, 2016)
    Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome ...
  • Byeon, Boseon; Kovalchuk, Igor (Nature ResearchArts and ScienceDepartment of Biological SciencesUniversity of Lethbridgehttps://doi.org/10.1038/srep37452, 2016)
    RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the deleted regions is present in human cells. Using ...
  • Mezbahuddin, Mohammad; Grant, Robert F.; Flanagan, Larry B. (European Geosciences UnionArts and ScienceDepartment of Biological SciencesAlberta Agriculture and ForestryUniversity of AlbertaUniversity of Lethbridgehttps://dx.doi.org/10.5194/bg-14-5507-2017, 2017)
    Water table depth (WTD) effects on net ecosystem CO2 exchange of boreal peatlands are largely mediated by hydrological effects on peat biogeochemistry and the ecophysiology of peatland vegetation. The lack of representation ...
  • Schwalm, Christopher R.; Williams, Christopher A.; Schaefer, Kevin; Anderson, Ryan S.; Arain, M. Altaf; Baker, Ian T.; Barr, Alan G.; Black, T. Andrew; Chen, Guangsheng; Chen, Jing M.; Ciais, Philippe; Davis, Kenneth J.; Desai, Ankur R.; Dietze, Michael C.; Dragoni, Danilo; Fischer, Marc L.; Flanagan, Larry B.; Grant, Robert F.; Gu, Lianhong; Hollinger, David Y.; Izaurralde, R. Cesar; Kucharik, Christopher J.; Lafleur, Peter M.; Law, Beverly E.; Li, Longhui; Li, Zhengpeng; Liu, Shuguang; Lokupitiya, Erandathie; Luo, Yiqi; Ma, Siyan; Margolis, Hank; Matamala, Roser; McCaughey, Harry; Monson, Russell K.; Oechel, Walter C.; Peng, Changhui; Poulter, Benjamin; Price, David T.; Ricciuto, Daniel M.; Riley, William J.; Sahoo, Alok Kumar; Sprintsin, Michael; Sun, Jianfeng; Tian, Hanqin; Tonitto, Christina; Verbeeck, Hans; Verma, Shashi B. (American Geophysical UnionArts and ScienceDepartment of Biological SciencesClark UniversityUniversity of Colorado at BoulderUniversity of MontanaMcMaster UniversityColorado State UniversityAtmospheric Science and Technology DirectorateUniversity of British ColumbiaAuburn UniversityUniversity of TorontoLaboratoire des Sciences du Climat et de l'EnvironmentPennsylvania State UniversityUniversity of Wisconsin-MadisonUniversity of Illinoise at Urbana-ChampaignIndiana UniversityLawrence Berkeley National LaboratoryUniversity of LethbridgeUniversity of AlbertaOak Ridge National LaboratoryUSDA Forest ServicePacific Northwest National LaboratoryUniversity of MarylandTrent UniversityOregon State UniversityASRC Research and Technology SolutionsEarth Resources Observation and Science CenterUniversity of OklahomaUniversity of CaliforniaUniversite LavalArgonne National LaboratoryQueen's UniversitySan Diego State UniversityUniversity of Quebec at MontrealSwiss Federal Research InstituteCanadian Forest ServicePrinceton UniversityCornell UniversityGhent UniversityUniversity of Nebraska-Lincolnhttps://dx.doi.org/10.1029/2009JG001229, 2010)
    Our current understanding of terrestrial carbon processes is represented in various models used to integrate and scale measurements of CO2 exchange from remote sensing and other spatiotemporal data. Yet assessments are ...
  • Dietze, Michael C.; Vargas, Rodrigo; Richardson, Andrew D.; Stoy, Paul C.; Barr, Alan G.; Anderson, Ryan S.; Arain, M. Altaf; Baker, Ian T.; Black, T. Andrew; Chen, Jing M.; Philippe, Ciais; Flanagan, Larry B.; Gough, Christopher M.; Grant, Robert F.; Hollinger, David Y.; Izaurralde, R. Cesar; Kucharik, Christopher J.; Lafleur, Peter M.; Liu, Shugang; Lokupitiya, Erandathie; Luo, Yiqi; Munger, J. William; Peng, Changhui; Poulter, Benjamin; Price, David T.; Ricciuto, Daniel M.; Riley, William J.; Sahoo, Alok Kumar; Schaefer, Kevin; Suyker, Andrew E.; Tian, Hanqin; Tonitto, Christina; Verbeeck, Hans; Verma, Shashi B.; Wang, Weifeng; Weng, Ensheng (American Geophysical UnionArts and ScienceDepartment of Biological SciencesUniversity of Illinoise at Urbana-ChampaignCentro de Investigacion Cientifica y de Educacion Superior de EnsenadaHarvard UniversityMontana State UniversityAtmospheric Science and Technology DirectorateUniversity of MontanaMcMaster UniversityColorado State UniversityUniversity of British ColumbiaUniversity of TorontoCentre d'Etudes Orme des MerisiersUniversity of LethbridgeVirginia Commonwealth UniversityUniversity of AlbertaU.S. Department of Agriculture Forest ServicePacific Northwest National LaboratoryUniversity of MarylandUniversity of Wisconsin-MadisonTrent UniversityEarth Resources Observation and Science CenterUniversity of OklahomaUniversity of Quebec at MontrealSwiss Federal Research InstituteLaboratoire des Sciences du Climat et de l'EnvironmentCanadian Forest ServiceOak Ridge National LaboratoryLawrence Berkeley National LaboratoryPrinceton UniversityUniversity of Colorado at BoulderUniversity of Nebraska-LincolnAuburn UniversityCornell UniversityGhent Universityhttps://dx.doi.org/10.1029/2011JG001661, 2011)
    Ecosystem models are important tools for diagnosing the carbon cycle and projecting its behavior across space and time. Despite the fact that ecosystems respond to drivers at multiple time scales, most assessments of model ...
  • Sims, Daniel A.; Rahman, Abdullah F.; Cordova, Vicente D.; El-Masri, Bassil Z.; Baldocchi, Dennis D.; Flanagan, Larry B.; Goldstein, Allen H.; Hollinger, David Y.; Misson, Laurent; Monson, Russell K.; Oechel, Walter C.; Schmid, Hans P.; Wofsy, Steven C.; Xu, Liukang (American Geophysical UnionArts and ScienceDepartment of Biological SciencesBall State UniversityTexas Tech UniversityUniversity of CaliforniaUniversity of LethbridgeNortheastern Research StationUniversity of Colorado at BoulderSan Diego State UniversityIndiana UniversityHavard UniversityLicor Incorporated Environmentalhttps://dx.doi.org/10.1029/2006JG000162, 2006)
    Carbon flux models based on light use efficiency (LUE), such as the MOD17 algorithm, have proved difficult to parameterize because of uncertainties in the LUE term, which is usually estimated from meteorological variables ...
  • Sulman, Benjamin N.; Desai, Ankur R.; Schroeder, Nicole M.; Ricciuto, Daniel M.; Barr, Alan G.; Richardson, Andrew D.; Flanagan, Larry B.; Lafleur, Peter M.; Tian, Hanqin; Chen, Guangsheng; Grant, Robert F.; Poulter, Benjamin; Verbeeck, Hans; Ciais, Philippe; Ringeval, Bruno; Baker, Ian T.; Schaefer, Kevin; Luo, Yiqi; Wong, Ensheng (American Geophysical UnionArts and ScienceDepartment of Biological SciencesUniversity of Wisconsin-MadisonOak Ridge National LaboratoryEnvironment CanadaHarvard UniversityUniversity of LethbridgeTrent UniversityAuburn UniversityUniversity of AlbertaSwiss Federal Research InstituteLaboratoire des Sciences du Climat et de l'EnvironmentGhent UniversityColorado State UniversityUniversity of Colorado at BoulderUniversity of Oklahomahttps://dx.doi.org/10.1029/2011JG001862, 2012)
    Northern peatlands are likely to be important in future carbon cycle-climate feedbacks due to their large carbon pools and vulnerability to hydrological change. Use of non-peatland-specific models could lead to bias in ...
  • Humphreys, Elyn R.; Lafleur, Peter M.; Flanagan, Larry B.; Hedstrom, Newell; Syed, Kamran H.; Glenn, Aaron J.; Granger, Raoul (American Geophysical UnionArts and ScienceDepartment of Biological SciencesTrent UniversityUniversity of LethbridgeNational Hydrology Research Centrehttps://dx.doi.org/10.1029/2005JG000111, 2006)
    Northern peatlands are a diverse group of ecosystems varying along a continuum of hydrological, chemical, and vegetation gradients. These ecosystems contain about one third of the global soil carbon pool, but it is uncertain ...
  • Grant, Robert F.; Flanagan, Larry B. (American Geophysical UnionArts and ScienceDepartment of Biological SciencesUniversity of AlbertaUniversity of Lethbridgehttps://dx.doi.org/10.1029/2006JG000302, 2007)
    The confidence with which we can model water deficit effects on grassland productivity is limited by uncertainty about the mechanisms, stomatal and nonstomatal, by which soil water deficits reduce CO2 uptake. We propose ...
  • Adkinson, Angela C.; Syed, Kamran H.; Flanagan, Larry B. (American Geophysical UnionArts and ScienceDepartment of Biological SciencesUniversity of Lethbridgehttps://dx.doi.org/10.1029/2010JG001512, 2011)
    The large belowground carbon stocks in northern peatland ecosystems are potentially susceptible to release because of the expected differential responses of photosynthesis and respiration to climate change. This study ...
  • Zaheer, Rahat; Bony-Dugat, Eric; Holman, Devon; Cousteix, Elodie; Xu, Yong; Munns, Krysty D.; Selinger, Lorna J.; Barbieri, Rutn; Alexander, Trevor W.; McAllister, Tim A.; Selinger, L. Brent (Public Library of ScienceArts and ScienceDepartment of Biological SciencesLethbridge Research and Development CentreUniversité Paris-SaclayUniversity of Lethbridgehttps://dx.doi.org/10.1371/journal.pone.0170050, 2017)
    Escherichia coli O157:H7 is a foodborne pathogen that colonizes ruminants. Cattle are considered the primary reservoir of E. coli O157:H7 with super-shedders, defined as individuals excreting>104 E. coli O157:H7 CFU g-1 ...
  • Laing, Chad R.; Buchanan, Cody J.; Taboada, Eduardo N.; Zhang, Yongxiang; Kropinski, Andrew; Villegas, Andre; Thomas, James E.; Gannon, Victor P. J. (BioMed CentralArts and ScienceDepartment of Biological SciencesPublic Health Agency of CanadaUniversity of Lethbridgehttps://doi.org/10.1186/1471-2105-11-461, 2010)
    Background: The pan-genome of a bacterial species consists of a core and an accessory gene pool. The accessory genome is thought to be an important source of genetic variability in bacterial populations and is gained through ...
  • Reti, Kristen L.; Thomas, Matthew C.; Yanke, L. Jay; Selinger, L. Brent; Inglis, G. Douglas (BioMed CentralArts and ScienceDepartment of Biological SciencesAgriculture and Agri-Food Canada Research CentreUniversity of Lethbridgehttps://dx.doi.org/10.1186/1757-4749-5-8, 2013)
    Background: Antimicrobial growth promoters (AGPs) are antimicrobial agents administered to livestock in feed for prolonged periods to enhance feed efficiency. Beef cattle are primarily finished in confined feeding operations ...
  • Dohms, Kimberly M.; Graham, Brendan A.; Burg, Theresa M. (WileyArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Windsorhttps://dx.doi.org/10.1002/ece3.3478, 2017)
    An increasing body of studies of widely distributed, high latitude species shows a variety of refugial locations and population genetic patterns. We examined the effects of glaciations and dispersal barriers on the popul ...
  • Macfarlane, Colin B. A.; Natola, Libby; Brown, Mike W. (WileyArts and ScienceDepartment of Biological SciencesUniversity of Lethbridgehttps://dx.doi.org/10.1002/ece3.2524, 2016)
    Using a combination of mitochondrial and z- linked sequences, microsatellite data, and spatio- geographic modeling, we examined historical and contemporary factors influencing the population genetic structure of the purple ...
  • Kovalchuk, Anna; Ilnytskyy, Yaroslav; Rodriquez-Juarez, Rocio; Katz, Amanda; Sidransky, David; Kolb, Bryan; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeChampions OncologyUniversity of Calgaryhttps://dx.doi.org/10.18632/oncotarget.19835, 2017)
    A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it ...
  • Wang, Bo; Li, Dongping; Sidler, Corinne; Rodriquez-Juarez, Rocio; Singh, Natasha; Heyns, Mieke; Ilnytskyy, Yaroslav; Bronson, Roderick T.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeQiqihar Medical UniversityThe Dana Farber/Harvard Comprehensive Cancer Centerhttps://doi.org/10.18632/oncotarget.3157, 2015)
    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide, and it has been linked to radiation exposure. As a well-defined oncogene, wild-type p53-induced phosphatase 1 (WIP1) plays ...
  • Kochan, David Z.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of Lethbridgehttps://doi.org/10.18632/oncotarget.4343, 2015)
    Breast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated ...

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