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dc.contributor.supervisor Kovalchuk, Olga
dc.contributor.author Baker, Mike
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2008-09-25T15:31:56Z
dc.date.available 2008-09-25T15:31:56Z
dc.date.issued 2008
dc.identifier.uri https://hdl.handle.net/10133/650
dc.description vii, 106 leaves : ill. ; 29 cm. en
dc.description.abstract For over 100 years, cancer radiation therapy has provided patients with increased survival rates. Despite this success, radiation exposure poses a threat to the progeny of exposed parents. It causes transgenerational genome instability that is linked to transgenerational carcinogenesis. The exact mechanisms in which this instability occurs have yet to be discovered. Current evidence points to their epigenetic nature, specifically changes in DNA methylation. Using mouse and rat models, this thesis investigated the transgenerational effects of radiation in the offspring from parents who received whole body or localized exposure to ionizing radiation (IR). Both types of exposure resulted in significant global DNA hypomethylation in the somatic tissues of the progeny. These changes were paralleled by the significantly decreased levels of methyltransferases and methyl-CpG-binding protein. In summary, our results suggest that both localized and whole body parental exposures to IR result in transgenerational epigenetic instability within the unexposed offspring. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Ionizing radiation en
dc.subject Rats -- Effect of radiation on en
dc.subject Mice -- Effect of radiation on en
dc.subject Cells -- Effect of radiation on en
dc.subject DNA -- Effect of radiation on en
dc.title Role of epigenetic changes in direct and indirect radiation effects en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Department of Biological Sciences en
dc.degree.level Masters


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