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dc.contributor.author Hehar, Harleen
dc.contributor.author Yeates, Keith
dc.contributor.author Kolb, Bryan
dc.contributor.author Esser, Michael J.
dc.contributor.author Mychasiuk, Richelle
dc.date.accessioned 2016-11-22T00:33:41Z
dc.date.available 2016-11-22T00:33:41Z
dc.date.issued 2015
dc.identifier.citation Hehar, H., Yeates, K., Kolb, B., Esser, M. J., & Mychasiuk, R. (2015). Impulsivity and concussion in juvenile rats: examining molecular and structural aspects of the frontostriatal pathway. PLoS ONE, 19(10), e0139842. doi:10.1371/journal.pone.0139842 en_US
dc.identifier.uri https://hdl.handle.net/10133/4724
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Impulsivity and poor executive control have been implicated in the pathogenesis of many developmental and neuropsychiatric disorders. Similarly, concussions/mild traumatic brain injuries (mTBI) have been associated with increased risk for neuropsychiatric disorders and the development of impulsivity and inattention. Researchers and epidemiologists have therefore considered whether or not concussions induce symptoms of attention-deficit/ hyperactivity disorder (ADHD), or merely unmask impulsive tendencies that were already present. The purpose of this study was to determine if a single concussion in adolescence could induce ADHD-like impulsivity and impaired response inhibition, and subsequently determine if inherent impulsivity prior to a pediatric mTBI would exacerbate post-concussion symptomology with a specific emphasis on impulsive and inattentive behaviours. As these behaviours are believed to be associated with the frontostriatal circuit involving the nucleus accumbens (NAc) and the prefrontal cortex (PFC), the expression patterns of 8 genes (Comt, Drd2, Drd3, Drd4, Maoa, Sert, Tph1, and Tph2) from these two regions were examined. In addition, Golgi-Cox staining of medium spiny neurons in the NAc provided a neuroanatomical examination of mTBI-induced structural changes. The study found that a single early brain injury could induce impulsivity and impairments in response inhibition that were more pronounced in males. Interestingly, when animals with inherent impulsivity experienced mTBI, injury-related deficits were exacerbated in female animals. The single concussion increased dendritic branching, but reduced synaptic density in the NAc, and these changes were likely associated with the increase in impulsivity. Finally, mTBI-induced impulsivity was associated with modifications to gene expression that differed dramatically from the gene expression pattern associated with inherent impulsivity, despite very similar behavioural phenotypes. Our findings suggest the need to tailor treatment strategies for mTBI in light of an individual’s premorbid characteristics, given significant differences in molecular profiles of the frontostriatal circuits that depend upon sex and the etiology of the behavioural phenotype en_US
dc.language.iso en_CA en_US
dc.publisher Public Library of Science en_US
dc.subject Impulsivity en_US
dc.subject Impulsive en_US
dc.subject Inattention en_US
dc.subject ADHD en_US
dc.subject Concussion en_US
dc.subject Brain injury en_US
dc.subject Mild traumatic brain injuries en_US
dc.subject mTBI en_US
dc.subject Frontostriatal en_US
dc.subject Brain--Concussion
dc.title Impulsivity and concussion in juvenile rats: examining molecular and structural aspects of the frontostriatal pathway en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Calgary en_US
dc.publisher.institution University of Lethbridge en_US


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