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dc.contributor.supervisor Kolb, Bryan
dc.contributor.author Comeau, Wendy L.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2016-02-24T21:14:59Z
dc.date.available 2016-02-24T21:14:59Z
dc.date.issued 2007
dc.identifier.uri https://hdl.handle.net/10133/4424
dc.description xix, 319 leaves: illustrations ; 29 cm
dc.description.abstract The effects of experience on developing and mature prefrontal brain circuitry and behaviour were investigated in rats using Ritalin, complex housing, and learning as tools. The results showed that Ritalin altered prefrontal cortical (PFC) circuitry and produced abnormal play behaviour and cognitive deficits into adulthood. Moreover, early stimulant exposure inhibited the robust anatomical changes typical after complex housing, demonstrating that early drug experience compromised cortical plasticity. Ritalin also altered adult PFC circuitry, but without enduring behavioural effects. Thus, it appeared that the mature brain was better able to compensate under adverse conditions. Nonetheless, novel experiences altered adult PFC circuitry with individual tasks producing unique patterns of change. Therefore, similar to other cortical regions the PFC was modified by experience. What was unique, however, was that experience-induced plasticity in the PFC appeared to be transient in adult animals, suggesting that once the task was learned the PFC was no longer required. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Ritalin en_US
dc.subject prefrontal cortical circuitry en_US
dc.subject cortical plasticity en_US
dc.subject experience-dependent changes en_US
dc.subject developing prefrontal cortex en_US
dc.subject adult prefrontal cortex en_US
dc.subject Prefrontal cortex -- Effect of drugs on -- Research
dc.subject Prefrontal cortex -- Physiology
dc.subject Methylphenidate
dc.subject Neuroplasticity -- Research
dc.subject Neuroplasticity -- Animal models
dc.subject Critical periods (Biology) -- Effect of drugs on
dc.subject Experience
dc.subject Developmental neurobiology
dc.subject Rats as laboratory animals
dc.subject Dissertations, Academic
dc.title The anatomical and behavioural correlates of experience en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Ph.D en_US
dc.proquestyes No en_US
dc.embargo No en_US


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