Faculty Research and Publications

Recent Submissions

  • Stuart, Daniel; Wetmore, Stacey D.; Gerken, Michael (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeCanadian Centre for Research in Advanced Fluorine Technologieshttps://doi.org/10.1016/j.jfluchem.2019.02.011, 2019)
    Lewis acid-base adducts between AsF5 and the ketones, acetone, cyclopentanone, and adamantanone, were synthesized from SO2 and CH2Cl2 solutions. These adducts, which contain O---As pnictogen bonding interactions, were found ...
  • Turnbull, Douglas; Wetmore, Stacey D.; Gerken, Michael (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeCanadian Centre for Research in Advanced Fluorine Technologieshttps://doi.org/10.1021/acs.inorgchem.9b00574, 2019)
    Amorphous [W(NC6F5)F4]x has been synthesized by the reaction of [C5H5NH][W(NC6F5)F5] with AsF5 in CH2Cl2. The reaction of [W(NC6F5)F4]x with CH3CN yields monomeric W(NC6F5)F4(NCCH3), whereas reaction with a sub-2-fold ...
  • Gray, Felicia; Cho, Hyo Je; Shukla, Shirish; He, Shihan; Harris, Ashley; Boytsov, Bohdan; Jaremko, Lukasz; Jaremko, Mariusz; Demeler, Borries; Lawlor, Elizabeth R.; Grembecka, Jolanta; Cierpicki, Tomasz (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganMax-Planck Institute of Biophysical ChemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1038/ncomms13343, 2016)
    BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions and is essential for its ...
  • Turnbull, Douglas; Hazendonk, Paul; Wetmore, Stacey D. (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeCanadian Centre for Research in Advanced Fluorine Technologieshttps://doi.org/10.1002/chem.202000424, 2020)
    The enhanced reactivity of [WF5]+ over WF6 has been exploited to access a neutral derivative of elusive WF5. The reaction of WF6(NC5H5)2 with [(CH3)3Si(NC5H5)][O3SCF3] in CH2Cl2 results in quantitative formation of ...
  • Kostiuk, Nathan; Goettel, James T.; Gerken, Michael (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeCanadian Centre for Research in Advanced Fluorine Technologieshttps://doi.org/10.1021/acs.inorgchem.0c01105, 2020)
    Chalcogen-bonding interactions of SF4 with the polycyclic amines DABCO (C6H12N2) and HMTA (C6H12N4) were studied by low-temperature Raman spectroscopy and X-ray crystallography, revealing the 2:1 adducts C6H12N2·2SF4 and ...
  • Turnbull, Douglas; Chaudhary, Praveen; Leenstra, Dakota; Hazendonk, Paul; Wetmore, Stacey D. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeCanadian Centre for Research in Advanced Fluorine Technologieshttps://dx.doi.org/10.1021/acs.inorgchem.0c02783?ref=pdf, 2020)
    The structure of [WOF4]4 has been reinvestigated by low-temperature X-ray crystallography and DFT (MN15/def2- SVPD) studies. Whereas the W4F4 ring of the tetramer is planar and disordered in the solid state, the optimized ...
  • Song, Chao; Chu, Xianxu; Zhu, Bifeng; Gerken, Michael; Zeng, Xiaoqing (ElsevierArts and ScienceDepartment of Chemistry and BiochemistrySoochow UniversityFudan UniversityUniversity of Lethbridgehttps://doi.org/10.1016/j.jfluchem.2020.109694, 2021)
    Two fluorine-substituted phosphoryl pseudohalides including the highly explosive diazide FP(O)(N3)2 and dii-socyanate FP(O)(NCO)2 have been synthesized and fully characterized with IR (gas-phase and noble-gas matrices), ...
  • Goettel, James T.; Kostiuk, Nathan; Gerken, Michael (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1002/anie.201302917, 2013)
    Solved at last: The crystal structure of solid SF4, which has a melting point of −121 °C, has been obtained. It exhibits weak intermolecular S⋅⋅⋅F interactions. A similar structural motif was observed within a layer of SF4 ...
  • Stuart, Daniel; Wetmore, Stacey D.; Gerken, Michael (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1002/anie.201710263, 2017)
    Protonated carbonyl compounds have been invoked as intermediates in many acid-catalyzed organic reactions. To gain key structural and electronic data about such intermediates, oxonium salts derived from five representative ...
  • Turnbull, Douglas; Wetmore, Stacey D.; Gerken, Michael (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1002/anie.201906600, 2019)
    Transition-metal hexafluorides do not exhibit fluoride-ion donor properties in the absence of donor ligands. We report the first synthesis of donor-stabilized [MF5]+ derived from a transition-metal hexafluoride via ...
  • Fan, Yanlin; Guo, Yusong R.; Yuan, Wang; Zhou, Ying; Holt, Matthew V.; Wang, Tao; Demeler, Borries; Young, Nicolas L.; Zhong, Weiwei; Tao, Yizhi J. (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryRice UniversityBaylor College of MedicineUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1371/journal.ppat.1006231, 2017)
    Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a ...
  • Turnbull, Douglas; Chaudhary, Praveen; Hazendonk, Paul; Wetmore, Stacey D.; Gerken, Michael (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://dx.doi.org/10.1021/acs.inorgchem.0c03679?ref=pdf, 2021)
    The Lewis-acid behavior of [SF3][MF6] (M = Sb, As) salts toward mono- and bidentate nitrogen bases was explored. Reactions of [SF3][MF6] with excesses of CH3CN and C5H5N yielded [SF3(L)2]+ (L = CH3CN, C5H5N) salts, whereas ...
  • Chaudhary, Praveen; Goettel, James T.; Mercier, Hélène P. A.; Sowlati-Hashjin, Shahin; Hazendonk, Paul; Gerken, Michael (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeMcMaster Universityhttps://doi.org/10.1002/chem.201406359, 2015)
    Sulfur tetrafluoride was shown to act as a Lewis acid towards organic nitrogen-bases, such as pyridine, 2,6-dimethylpyridine, 4-methylpyridine, and 4-dimethylaminopyridine. The SF4·NC5H5, SF4·2,6-NC5H3(CH3)2, ...
  • Stoutjesdyk, Marielle; Henrickson, Amy; Minors, Geoff; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01434-z, 2020)
    Experiments performed in the analytical ultracentrifuge (AUC) measure sedimentation and diffusion coefficients, as well as the partial concentration of colloidal mixtures of molecules in the solution phase. From this ...
  • Stoutjesdyk, Marielle; Brookes, Emre; Henrickson, Amy; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01482-5, 2020)
    A method is described to accurately measure the compressibility of liquids using an analytical ultracentrifuge. The method makes use of very large pressure gradients, which can be generated in the analytical ultracentrifuge ...
  • Wang, Zhonghua; Bhattacharya, Akash; White, Tommy; Buffone, Cindy; McCabe, Aine; Nguyen, Laura A.; Shepard, Caitlin N.; Pardo, Sammy; Kim, Baek; Weintraub, Susan T.; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science CenterAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1016/j.celrep.2018.06.090, 2018)
    SAMHD1 is a dNTP triphosphohydrolase (dNTPase)that impairs retroviral replication in a subset of non-cycling immune cells. Here we show that SAMHD1is a redox-sensitive enzyme and identify threeredox-active cysteines within ...
  • Adusei-Danso, Felix; Khaja, Faisal Tarique; DeSantis, Micaela; Jeffrey, Philip D.; Dubnau, Eugenie; Demeler, Borries; Neiditch, Matthew B.; Dubnau, David (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityCenter of New Jersey Medical SchoolPrinceton UniversityUniversity of Lethbridgehttps://doi.org/10.1128/mBio.01841-19, 2019)
    In Bacillus subtilis, the RicA (YmcA), RicF (YlbF), and RicT (YaaT) proteins accelerate the phosphorylation of the transcription factor Spo0A, contributing to ge netic competence, sporulation, and biofilm formation, and ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...
  • Turnbull, Douglas; Gerken, MIchael (Arts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1107/S2056989020009767, 2020)
    Crystals of 1,10-phenanthrolinium penta­fluorido­oxidotungstate(VI), (1,10-phen-H)[WOF5] (1,10-phen = 1,10-phenanthroline, C12H8N2), were obtained upon hydrolysis of WF6(1,10-phen) in CH3CN at 193 K. The (1,10-phen-H)[WOF5] ...
  • Obi, Juliet O.; Lubula, Mulu Y.; Cornilescu, Gabriel; Henrickson, Amy; McGuire, Kara; Evans, Chiara M.; Phillips, Margaret; Boyson, Samuel P.; Demeler, Borries; Markley, John L.; Glass, Karen C. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of Wisconsin-MadisonUniversity of Lethbridgehttps://doi.org/10.1016/j.crstbi.2020.05.001, 2020)
    Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead toaltered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHDfinger ...

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