Chemistry & Biochemistry

 

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  • Soares, Barbara S.; Rocha, Surza Lucia G.; Bastos, Viviane A.; Lima, Diogo B.; Carvalho, Paulo C.; Gozzo, Fabio C.; Demeler, Borries; Williams, Tayler L.; Arnold, Janelle; Henrickson, Amy; Jorgensen, Thomas J. D.; Souza, Tatiana A. C. B.; Perales, Jonas; Valente, Richard H.; Lomonte, Bruno; Gomes-Neto, Francisco; Neves-Ferreira, Ana Gisele C. (Frontiers Research FoundationArts and ScienceDepartment of Chemistry and BiochemistryOswaldo Cruz InstituteLeibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)Carlos Chagas InstituteUniversity of CampinasUniversity of Texas Health Science Center at San AntonioUniversity of LethbridgeUniversity of MontanaPrinceton UniversityUniversity of Southern DenmarkUniversity of Costa Ricahttps://doi.org/10.3389/fmolb.2021.787368, 2022)
    DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
  • D'Souza, Michael H.; Mrozowich, Tyler; Badmalia, Maulik D.; Geeraert, Mitchell; Frederickson, Angela; Henrickson, Amy; Demeler, Borries; Wolfinger, Michael T.; Patel, Trushar R. (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryUniversity of MontanaUniversity of ViennaUniversity of Albertahttps://doi.org/10.1093/nar/gkac414, 2022)
    Human Long Intergenic Noncoding RNA-p21 (LincRNA-p21) is a regulatory noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also critical in down-regulating many p53 target genes through its ...
  • Evans, Chiara M.; Phillips, Margaret; Malone, Kiera L.; Tonelli, Marco; Cornilescu, Gabriel; Cornilescu, Claudia; Holton, Simon J.; Gorjánácz, Mátyás; Wang, Liping; Carlson, Samuel; Gay, Jamie C.; Nix, Jay C.; Demeler, Borries; Markley, John L.; Glass, Karen C. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of VermontUniversity of Wisconsin-MadisonBayer AGUniversity of Texas Health San AntonioMolecular Biology ConsortiumUniversity of Lethbridgehttps://doi.org/10.3390/ijms22179128, 2021)
    The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four -helices. ATAD2 functions as a coactivator of the androgen and estrogen receptors as ...
  • Guimaraes, Ivelise D. L.; Marszaukowski, Flávia; Rutka, Priscila B.; Borge, Luis F.; Ribeiro, Renan A. P.; Ricardo de Lazaro, Sergio; Castellen, Patrícia; Sagoe-Wagner, Araba; Golsteyn, Roy M.; Boeré, René T.; Wohnrath, Karen (ElsevierArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryUniversidade Estadual de Ponta GrossaUniversidade do Estado de Minas GeraisInstituto Federal Catarinense, Rua das RosasUniversity of Lethbridgehttps://doi.org/10.1016/j.poly.2022.115980, 2022)
    Ruthenium-based anticancer agents have created a center of attention in the field of inorganic medicinal chemistry. The first fully characterized cationic ruthenium(II)-arene complexes [Ru(η6-p-cymene) (PAr3)LNCl]+ with ...
  • Ibrahim, Mukaila A.; Boeré, René T. (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1039/D2NJ00169A, 2022)
    New structure determinations of CuSO4, CuSO4 H2O, CuSO4 3H2O and CuSO4 5H2O are reported from X-ray diffraction experiments at 100 (1) K. Combined density functional theory (ORCA) and non-spherical atomic scattering ...
  • Marszaukowski, Flávia; Boeré, René T.; Wohnrath, Karen (ACS PublicationsArts and ScienceDepartment of Chemistry and BiochemistryUniversidade Estadual de Ponta GrossaUniversity of Lethbridgehttps://doi.org/10.1021/acs.cgd.2c00020, 2022)
    Synthesis and molecular and supramolecular structures of a series of triarylphosphines P(Ph)3–n{4-RO-3,5-(tBu)2-C6H2}n (n = 1, 3; R = SiMe3, H) are reported. Chemical oxidation products E=P(Ph)3–n{4-RO-3,5-(tBu)2-C6H2}n ...
  • Ramachandran, Mridhul R. K.; Schnakenburg, Gregor; Majumdar, Moumita; Kelemen, Zsolt; Gal, Dalma; Nyulaszi, Laszlo; Boeré, René T.; Streubel, Rainer K. (ACS PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRheinische Friedrich-Wilhelms-Universitat BonnIndian Institute of Science Education and ResearchBudapest University of Technology and EconomicsUniversity of Lethbridgehttps://doi.org/10.1021/acs.inorgchem.1c03620, 2022)
    Anionic 1,4-dihydro-1,4-diphosphinines were synthesized from tricyclic 1,4-diphosphinines and isolated as blue powdery salts M[2a–2c]. Reaction of solutions of these monoanions with iodomethane led to P-methylated compounds ...
  • Drescher, Sam L.; Forfar, Christopher P.; Boeré, René T.; Hayes, Paul G. (Arts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1107/S2056989021009221, 2021)
    The compound bis­{μ3-2,5-bis­[N-(4-iso­propyl­phen­yl)-P,P-di­phenyl­phospho­r­im­i­do­yl]pyrrol-1-ido-κ3N:N′:N′′}tris­ilver(I) tri­fluoro­methane­sulfonate deuterated benzene penta­solvate, [Ag3(C46H44N3P2)2](CF3O3S)·5C6D6, ...
  • Marasco, Olivia N. J. M.; Roussel, Marc R.; Thakor, Nehal (ElsevierArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1016/j.mbs.2021.108762, 2022)
    ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation ...
  • Villarreal, Oscar D.; Chen, Liao Y.; Whetten, Robert L.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas at San AntonioUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.5b09864, 2015)
    Nanometer-sized gold particles (AuNPs) are of peculiar interest because their behaviors in an aqueous solution are sensitive to changes in environmental factors including the size and shape of the solute ions. In order to ...
  • Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J.; Dewdney, Tamaria G.; Demeler, Borries; Cherepanov, Peter; Lyumkis, Dmitry; Engelman, Alan N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryHarvard Medical SchoolThe Salk Institute for Biological StudiesThe Francis Crick InstituteUniversity of Texas Health Science Center at San AntonioImperial College LondonUniversity of Lethbridgehttps://doi.org/10.1038/nature16955, 2016)
    Retroviral integrase catalyses the integration of viral DNA into host target DNA, which is an essential step in the life cycle of all retroviruses1. Previous structural characterization of integrase–viral DNA complexes, ...
  • Alvarez, Marcos M.; Chen, Jenny; Plascencia-Villa, German; Black, David M.; Griffiths, Wendell P.; Garzon, Ignacio L.; Jose-Yacaman, Miguel; Demeler, Borrie; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasThermoFisher ScientificUniversidad Nacional Autonoma de MexicoUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.6b04525, 2016)
    Experimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, ...
  • Rubio-Marrero, Eva N.; Vincelli, Gabriele; Jeffries, Cy M.; Shaikh, Tanvir R.; Pakos, Irene S.; Ranaivoson, Fanomezana M.; von Daake, Sventja; Demeler, Borries; De Jaco, Antonella; Perkins, Guy; Ellisman, Mark H.; Trewhella, Jill; Comoletti, Davide (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityUniversity of SydneyMasaryk UniversityUniversity of Texas Health Science Center at San AntonioSapienza University of RomeUniversity of California San DiegoUniversity of UtahUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M115.705681, 2015)
    Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including ...
  • Bhattacharya, Akash; Wang, Zhonghua; White, Tommy; Buffone, Cindy; Nguyen, Laura A.; Shepard, Caitlin N.; Kim, Baek; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1038/srep31353, 2016)
    SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but ...
  • Wong, Sarah J.; Gearhart, Micah D.; Taylor, Alexander B.; Nanyes, David R.; Ha, Daniel J.; Robinson, Angela K.; Artigas, Jason A.; Lee, Oliver J.; Demeler, Borries; Hart, P. John; Bardwell, Vivian J.; Kim, Chongwoo A. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of MinnesotaMidwestern UniversitySouth Texas Veterans Health Care SystemUniversity of Lethbridgehttps://doi.org/10.1016/j.str.2016.07.011, 2016)
    KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex 1 (PRC1.1) to CpG islands, facilitating gene repres sion. We investigated the molecular basis of recruit ment using in vitro ...
  • Karabudak, Engin; Brookes, Emre; Lesnyak, Vladimir; Gaponik, Nikolai; Eychmuller, Alexander; Walter, Johannes; Segets, Doris; Peukert, Wolfgang; Wohlleben, Wendel; Demeler, Borries; Colfen, Helmut (WileyArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute of Colloids and InterfacesIzmir Institute of TechnologyUniversity of Texas Health Science Center at San AntonioTU DresdenFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)BASE SEUniversity of Lethbridgehttps://doi.org/10.1002/anie.201603844, 2016)
    We report an unsurpassed solution characterization technique based on analytical ultracentrifugation, which demonstrates exceptional potential for resolving particle sizes in solution with sub-nm resolution. We achieve ...
  • Smirnova, Ekaterina; Kwan, Jamie J.; Siu, Ryan; Gao, Xin; Zoidl, Georg; Demeler, Borries; Saridakis, Vivian; Donaldson, Logan W. (BioMed CentralArts and ScienceDepartment of Chemistry and BiochemistryYork UniversityKing Abdullah University of Science and TechnologyUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1186/s12964-016-0140-3, 2016)
    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 ...
  • Walter, Johannes; Gorbet, Gary E.; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)University of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1039/C6AN02236G, 2017)
    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core–shell NPs by means of ...
  • Lopez, Priscilla; Lara, Humberto H.; Mullins, Sean M.; Black, David M.; Ramsower, Heidi M.; Alvarez, Marcos M.; Williams, Tayler L.; Lopez-Lozano, Xochitl; Weissker, Hans-Christian; Garcia, A. Patricio; Garzon, Ignacio L.; Demeler, Borries; Lopez-Ribot, Jose Luis; Yacaman, Miguel J.; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasUniversity of Texas Health Science Center at San AntonioAix Marseille UniversityUniversidad Nacional Autonoma de MexicoUniversity of Lethbridgehttps://doi.org/10.1021/acsanm.8b00069, 2018)
    Here we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its ...
  • Wagner, Jonathan M.; Christensen, Devin E.; Bhattacharya, Akash; Dawidziak, Daria M.; Roganowicz, Marcin D.; Wan, Yueping; Pumroy, Ruth A.; Demeler, Borries; Ivanov, Dmitri N.; Ganser-Pornillos, Barbie K.; Sundquist, Wesley I.; Pornillos, Owen (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VirginiaUniversity of UtahUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1128/JVI.01563-17, 2018)
    Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, ...

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