Rhodium-mediated assembly of new heterocycles: from borylenes to oxaboroles
| dc.contributor.author | Hsiang, Shou-Jen | |
| dc.contributor.author | Hayes, Paul G. | |
| dc.date.accessioned | 2025-07-18T21:22:31Z | |
| dc.date.available | 2025-07-18T21:22:31Z | |
| dc.date.issued | 2025 | |
| dc.description | Open access article. Creative Commons Attribution 4.0 International license (CC BY 4.0) applies | |
| dc.description.abstract | Base-stabilized rhodium borylene complex κ2-L(CO)Rh(BMes), 2; κ2-L=κ2-NN’-Rh,κ1-N−B-(2,5-[iPr2P=N(4-iPrC6H4)]2-N’(C4H2)−); Mes=mesityl, reacts with a series of alkynes (PhC≡C—R; R=Ph, Me, CO2Et, H) to yield unique structures whereby the alkyne has regioselectively added across boron and the carbon atom of a CO ligand. The resulting complexes, LRh[C(O)C(Ph)C(R)B(Mes)], 3R, react with additional CO to afford cycle-containing products, L(CO)Rhmathematical equation ), 5R, that ultimately release highly functionalized organic heterocycles of the form mathematical equation =NPipp (Pipp=4-iPrC6H4), 6. These oxaboroles, which were assembled from a primary hydroborane, CO, an alkyne, and an azide-generated NPipp, are structurally analogous to two of the five boron-containing therapeutics approved by the FDA. | |
| dc.description.peer-review | No | |
| dc.identifier.citation | Hsiang, S.-J., & Hayes, Paul G. (2025). Rhodium-mediated assembly of new heterocycles: From borylenes to oxaboroles. Angewandte Chemie Int. Ed., 64(10), Article e202421, https://doi.org/10.1002/anie.202421302302 | |
| dc.identifier.uri | https://hdl.handle.net/10133/7076 | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.publisher.department | Department of Chemistry and Biochemistry | |
| dc.publisher.faculty | Arts and Science | |
| dc.publisher.institution | University of Lethbridge | |
| dc.publisher.url | https://doi.org/10.1002/anie.202421302 | |
| dc.subject | Cyclization | |
| dc.subject | Alkyne | |
| dc.subject | Borylene | |
| dc.subject | Rhodium | |
| dc.subject | Oxaborale | |
| dc.title | Rhodium-mediated assembly of new heterocycles: from borylenes to oxaboroles | |
| dc.type | Article |