Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats

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dc.contributor.authorSpanswick, Simon C.
dc.contributor.authorSutherland, Robert J.
dc.date.accessioned2019-04-04T21:16:09Z
dc.date.available2019-04-04T21:16:09Z
dc.date.issued2010
dc.descriptionSherpa Romeo green journal. Permission to archive published version.en_US
dc.description.abstractChronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important.We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationSpanswick, S. C., & Sutherland, R. J. (2010). Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats. Learning and Memory, 17(5), 241-245. Retrieved from http://www.learnmem.org/cgi/doi/10.1101/lm.1746710.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5322
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://dx.doi.org/10.1101/lm.1746710
dc.subjectHippocampalen_US
dc.subjectGranule cellsen_US
dc.subjectMemory deficitsen_US
dc.subjectObject memoryen_US
dc.subjectADX ratsen_US
dc.subjectObject/context mismatchen_US
dc.subjectContext memoriesen_US
dc.subject.lcshAdrenalectomy
dc.subject.lcshRats as laboratory animals
dc.subject.lcshCorticosterone
dc.subject.lcshMemory--Research
dc.subject.lcshHippocampus (Brain)--Research
dc.subject.lcshDentate gyrus--Research
dc.subject.lcshBrain--Research
dc.titleObject/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in ratsen_US
dc.typeArticleen_US
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