Corticosterone response to gestational stress and postpartum memory function in mice

Simple item page
dc.contributor.authorJafari, Zahra
dc.contributor.authorMehla, Jogender
dc.contributor.authorAfrashteh, Navvab
dc.contributor.authorKolb, Bryan
dc.contributor.authorMohajerani, Majid H.
dc.date.accessioned2018-11-28T04:54:44Z
dc.date.available2018-11-28T04:54:44Z
dc.date.issued2017
dc.descriptionOpen access; distributed under the terms of the Creative Commons Attribution Licenseen_US
dc.description.abstractMaternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors. Pregnant C57BL/6 mice were randomly assigned to either one of two stress conditions or a control condition. The noise stress (NS) was induced by presenting a loud intermittent 3000 Hz frequency on gestational days (GDs) 12, 14, and 16 for 24 hours, whereas the physical stress (PS) consisted of restraint and exposure to an elevated platform on GDs 12–16. Plasma corticosterone level was collected on GDs 11 and 17, and Morris water task (MWT) was carried out 30 days after parturition. Compared to the control group, the level of corticosterone in the stressed groups was significantly increased on GD17 relative to GD11. Significantly longer swim time and lower swim speed were observed in both stressed groups relative to the control group. Probe time was significantly shorter in the NS group than the other groups. The delta corticosterone level was significantly correlated with the swim time as well as the probe time in the three groups. Given the results, the adverse effects of gestational noise exposure on the hypothalamic pituitary-adrenal (HPA) axis activation and postpartum spatial learning and memory function were as large as/ or a bit stronger than the physical stresses. The findings suggest the significance of conservation against loud noise exposure in daily living, as well as need to further notice to the different aspects of gestational stress in mothers’ behavior like offspring.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationJafari, Z., Mehla, J., Afrashteh, N. Kolb, B. E., & Mohajerani, M. H. (2017). Corticosterone response to gestational stress and postpartum memory function in mice. PLoS ONE, 12(7), e0180306. https://doi.org/10.1371/journal.pone.0180306en_US
dc.identifier.urihttps://hdl.handle.net/10133/5251
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionIran University of Medical Science (IUMS)en_US
dc.subjectGestational stressen_US
dc.subjectMaternal stressen_US
dc.subjectGestational corticosteroneen_US
dc.subjectCorticosterone fluctuationsen_US
dc.subjectGestational noise exposureen_US
dc.subjectSpatial cognitionen_US
dc.subjectPostpartum memoryen_US
dc.subjectPregnant mice
dc.subject.lcshCorticosterone
dc.subject.lcshNoise--Health aspects
dc.subject.lcshMice--Effects of noise on
dc.subject.lcshMice--Research
dc.titleCorticosterone response to gestational stress and postpartum memory function in miceen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kolb corticosterone response.pdf
Size:
1.23 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Kolb, Bryan