Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells

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dc.contributor.authorSwift, Lucy H.
dc.contributor.authorGolsteyn, Roy
dc.date.accessioned2016-07-05T18:20:11Z
dc.date.available2016-07-05T18:20:11Z
dc.date.issued2014
dc.descriptionOpen accessen_US
dc.description.abstractWhen a human cell detects damaged DNA, it initiates the DNA damage response (DDR) that permits it to repair the damage and avoid transmitting it to daughter cells. Despite this response, changes to the genome occur and some cells, such as proliferating cancer cells, are prone to genome instability. The cellular processes that lead to genomic changes after a genotoxic event are not well understood. Our research focuses on the relationship between genotoxic cancer drugs and checkpoint adaptation, which is the process of mitosis with damaged DNA. We examine the types of DNA damage induced by widely used cancer drugs and describe their effects upon proliferating cancer cells. There is evidence that cell death caused by genotoxic cancer drugs in some cases includes exiting a DNA damage cell cycle arrest and entry into mitosis. Furthermore, some cells are able to survive this process at a time when the genome is most susceptible to change or rearrangement. Checkpoint adaptation is poorly characterised in human cells; we predict that increasing our understanding of this pathway may help to understand genomic instability in cancer cells and provide insight into methods to improve the efficacy of current cancer therapies.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationSwift, L.H., & Golsteyn, R.M. (2014). Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells. International Journal of Molecular Sciences, 15, 3403-3431. doi:10.3390/ijms15033403en_US
dc.identifier.urihttps://hdl.handle.net/10133/4551
dc.language.isoen_CAen_US
dc.publisherM D P I A Gen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectCdk1en_US
dc.subjectMitosisen_US
dc.subjectTissue cultureen_US
dc.subjectAnti-cancer drugsen_US
dc.subjectDNA repairen_US
dc.titleGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsen_US
dc.typeArticleen_US
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