A mathematical model of the biochemical network underlying left-right asymmetry establishment in mammals

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dc.contributor.authorRoussel, Catharine J.
dc.contributor.authorRoussel, Marc R.
dc.date.accessioned2019-05-16T17:23:38Z
dc.date.available2019-05-16T17:23:38Z
dc.date.issued2018
dc.descriptionAccepted author manuscript.en_US
dc.description.abstractThe expression of the TGF-β protein Nodal on the left side of vertebrate embryos is a determining event in the development of internal-organ asymmetry. We present a mathematical model for the control of the expression of Nodal and its antagonist Lefty consisting entirely of realistic elementary reactions. We analyze the model in the absence of Lefty and find a wide range of parameters over which bistability (two stable steady states) is observed, with one stable steady state a low-Nodal state corresponding to the right-hand developmental fate, and the other a high-Nodal state corresponding to the left. We find that bistability requires a transcription factor containing two molecules of phosphorylated Smad2. A numerical survey of the full model, including Lefty, shows the effects of Lefty on the potential for bistability, and on the conditions that lead to the system reaching one or the other steady state.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationRoussel, C. J., & Roussel, M. R. (2018). A mathematical model of the biochemical network underlying left-right asymmetry establishment in mammals. BioSystems, 173, 281-297. doi:10.1016/j.biosystems.2018.10.003en_US
dc.identifier.urihttps://hdl.handle.net/10133/5358
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.doi
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.1016/j.biosystems.2018.10.003
dc.subjectDevelopmenten_US
dc.subjectAsymmetryen_US
dc.subjectMouseen_US
dc.subjectNodalen_US
dc.subjectLeftyen_US
dc.subjectMathematical modelen_US
dc.subjectBiochemical network
dc.subject.lcshAsymmetry (Chemistry)
dc.subject.lcshBistability
dc.titleA mathematical model of the biochemical network underlying left-right asymmetry establishment in mammalsen_US
dc.typeArticleen_US
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