Barriers to developing a valid rodent model of Alzheimer's disease: from behavioral analysis to etiological mechanisms

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dc.contributor.authorGidyk, Darryl C.
dc.contributor.authorDeibel, Scott H.
dc.contributor.authorHong, Nancy S.
dc.contributor.authorMcDonald, Robert J.
dc.date.accessioned2018-11-01T16:49:51Z
dc.date.available2018-11-01T16:49:51Z
dc.date.issued2015
dc.descriptionSherpa Romeo green journal; open accessen_US
dc.description.abstractSporadic Alzheimer’s disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted, however, the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer potential solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationGidyk, D. C., Deibel, S. H., Hong, N. S., & McDonald, R. J. (2015). Barriers to developing a valid rodent model of Alzheimer's disease: From behavioral analysis to etiological mechanisms. Frontiers in Neuroscience, 9(245). doi:10.3389/fnins.2015.00245.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5231
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectRodent modelen_US
dc.subjectAgingen_US
dc.subjectHippocampusen_US
dc.subjectMemoryen_US
dc.subjectCognitionen_US
dc.subjectNeurodegenerationen_US
dc.subjectDementiaen_US
dc.titleBarriers to developing a valid rodent model of Alzheimer's disease: from behavioral analysis to etiological mechanismsen_US
dc.typeArticleen_US
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