Effects of TCB-2 on Alzheimer's neuropathology
| dc.contributor.author | Cocco, Giulia | |
| dc.contributor.supervisor | Sutherland, Robert J. | |
| dc.date.accessioned | 2022-07-27T22:19:10Z | |
| dc.date.available | 2022-07-27T22:19:10Z | |
| dc.date.issued | 2022 | |
| dc.description | 4o pages | en_US |
| dc.description.abstract | Background: In recent years there’s been a surging interest in the pharmacological benefits of serotonin receptor (5-HTR) agonists to treat psychiatric disorders, one of them being Alzheimer’s Disease (AD). Research has hinted at the effects of these 5-HTR agonists on hippocampal (HPC) neurogenesis, Amyloid-b (Ab) plaque deposition and microglial activation. These are all hallmark biomarkers of AD. In light of the rise in dementia diagnoses, studies should examine different methods to moderate these symptoms. Objective: This study shows the effects of the drug (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide (TCB-2) as a candidate to ameliorate AD biomarkers of neuropathology in the APPNL-G-F mouse model at 6 and 10 months of age (early and late stages). Methods: Fourteen APPNL-G-F mice were fed 0.35g of Nutella®. The treatment group received 5 mg/kg of TCB-2 whereas the controls received the vehicle only. Feeding occurred every 3 days for the length of 29 days. Afterward, they were tested on the Novel Object Recognition (NOR) task for 6 days and subsequently perfused to collect their brains and apply immunohistochemistry analysis. Results: The TCB-2 treatment was significantly more effective at decreasing A plaque count in the younger cohort, resulting in a trend of cognitive enhancement as well. It provided anti-inflammatory aid and decreased HPC surface area across all ages. Conclusion: Due to the ambiguous role of serotonin in learning and memory, our research hopes to expand its literature. The results prove that there’s potential for 5-HTR agonists to be used as medical treatments to prevent the development of AD neuropathology. | |
| dc.identifier.uri | https://hdl.handle.net/10133/6292 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | University of Lethbridge, Dept. of Neuroscience | |
| dc.publisher.department | Department of Neuroscience | |
| dc.publisher.faculty | Canadian Centre for Behavioural Neuroscience | en_US |
| dc.publisher.faculty | Arts and Science | |
| dc.subject | TCB-2 | |
| dc.subject | AD neuropathology | |
| dc.subject | 5-HTR agonists | |
| dc.subject.lcsh | Alzheimer's disease--Research | |
| dc.title | Effects of TCB-2 on Alzheimer's neuropathology | en_US |
| dc.type | Honours Thesis | en_US |